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In situ green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

2019-05Journal article Open access
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dc.contributor.authorCabral, C.S.D.
dc.contributor.authorMiguel, Sónia
dc.contributor.authorDiogo, Duarte Miguel De Melo
dc.contributor.authorLouro, Ricardo
dc.contributor.authorCorreia, Ilidio
dc.date.accessioned2019-03-07T17:15:50Z
dc.date.available2022-03-08T01:30:16Z
dc.date.issued2019-05
dc.description.abstractThe incorporation of reduced graphene oxide (rGO) nanomaterials into scaffolds structure can be explored to enhance the properties of these 3D matrices in bone regeneration applications. However, the weak water solubility and poor colloidal stability of rGO have hindered its incorporation in blends aimed to produce scaffolds by 3D printing. Furthermore, rGO is generally obtained by treating graphene oxide (GO) with hydrazine hydrate, which is a highly hazardous reducing agent. To overcome these problems, herein a novel environmentally-friendly method was developed to assemble 3D printed scaffolds incorporating rGO. Such was achieved through the in situ reduction mediated by l-Ascorbic acid of the GO already present on tricalcium phosphate/gelatin/chitosan scaffolds. The scaffolds functionalized with rGO through the in situ method (TGC_irGO) displayed enhanced wettability and improved mechanical properties without impairing their porosity when compared to their equivalents functionalized with GO and non-functionalized scaffolds (TGC_GO and TGC, respectively). Moreover, the TGC_irGO scaffolds displayed an improved calcium deposition at their surface and an enhanced alkaline phosphatase (ALP) activity, along 21 days of incubation. Additionally, scaffolds also displayed antimicrobial activity without compromising osteoblasts’ viability and proliferation. Such features reveal the potential of the TGC_irGO scaffolds for bone tissue regeneration applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.carbon.2019.01.100pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6895
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.subject3D scaffoldspt_PT
dc.subjectBone Tissue Engineeringpt_PT
dc.subjectGreen Chemistrypt_PT
dc.subjectRapid prototypingpt_PT
dc.subjectReduced graphene oxidept_PT
dc.titleIn situ green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.endPage523pt_PT
oaire.citation.startPage513pt_PT
oaire.citation.titleCarbonpt_PT
oaire.citation.volume146pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameCabral
person.familyNamePereira Miguel
person.familyNameMiguel de Melo Diogo
person.familyNameLouro
person.familyNameJoaquim Sobreira Correia
person.givenNameCátia Solange Duarte
person.givenNameSónia Alexandra
person.givenNameDuarte
person.givenNameRicardo
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos de autor foram cedidos à editora.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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