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Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration

2019Journal article Open access
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dc.contributor.authorSequeira, Rosa Maria Saraiva
dc.contributor.authorMiguel, Sónia
dc.contributor.authorCabral, Cátia S. D.
dc.contributor.authorMoreira, André
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-08-30T13:16:10Z
dc.date.available2021-08-30T00:30:10Z
dc.date.issued2019
dc.description.abstractNanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranes-based drug delivery systems to be used as wound dressings.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2019.118640pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7213
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517319306854?via%3Dihubpt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectElectrospun membranespt_PT
dc.subjectIbuprofenpt_PT
dc.subjectLavender oilpt_PT
dc.subjectWound dressingpt_PT
dc.titleDevelopment of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.startPage118640pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume570pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameCabral
person.familyNameMoreira
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameCátia Solange Duarte
person.givenNameAndré Ferreira
person.givenNamePaula
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos do artigo foram cedidos à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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