Publication
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration
dc.contributor.author | Sequeira, Rosa Maria Saraiva | |
dc.contributor.author | Miguel, Sónia | |
dc.contributor.author | Cabral, Cátia S. D. | |
dc.contributor.author | Moreira, André | |
dc.contributor.author | Ferreira, Paula | |
dc.contributor.author | Correia, I.J. | |
dc.date.accessioned | 2019-08-30T13:16:10Z | |
dc.date.available | 2021-08-30T00:30:10Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranes-based drug delivery systems to be used as wound dressings. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.1016/j.ijpharm.2019.118640 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10400.6/7213 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing | |
dc.relation | Development of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378517319306854?via%3Dihub | pt_PT |
dc.subject | Drug delivery systems | pt_PT |
dc.subject | Electrospun membranes | pt_PT |
dc.subject | Ibuprofen | pt_PT |
dc.subject | Lavender oil | pt_PT |
dc.subject | Wound dressing | pt_PT |
dc.title | Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing | |
oaire.awardTitle | Development of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT | |
oaire.citation.conferencePlace | Holanda | pt_PT |
oaire.citation.startPage | 118640 | pt_PT |
oaire.citation.title | International Journal of Pharmaceutics | pt_PT |
oaire.citation.volume | 570 | pt_PT |
oaire.fundingStream | 5876 | |
oaire.fundingStream | POR_CENTRO | |
oaire.fundingStream | POR_CENTRO | |
person.familyName | Pereira Miguel | |
person.familyName | Cabral | |
person.familyName | Moreira | |
person.familyName | Cristina Nunes Ferreira Calvinho | |
person.familyName | Joaquim Sobreira Correia | |
person.givenName | Sónia Alexandra | |
person.givenName | Cátia Solange Duarte | |
person.givenName | André Ferreira | |
person.givenName | Paula | |
person.givenName | Ilídio | |
person.identifier | GX0L2QAAAAJ | |
person.identifier | 1161643 | |
person.identifier | UMbJ1KMAAAAJ | |
person.identifier.ciencia-id | 1A13-ABC0-C32C | |
person.identifier.ciencia-id | 8D18-367B-2572 | |
person.identifier.ciencia-id | 4C1E-012B-83CE | |
person.identifier.ciencia-id | A119-FFB8-0899 | |
person.identifier.ciencia-id | F610-7373-DC81 | |
person.identifier.orcid | 0000-0001-7274-0399 | |
person.identifier.orcid | 0000-0002-4247-4816 | |
person.identifier.orcid | 0000-0002-0604-2506 | |
person.identifier.orcid | 0000-0003-3393-4427 | |
person.identifier.orcid | 0000-0003-1613-9675 | |
person.identifier.scopus-author-id | 55638166400 | |
person.identifier.scopus-author-id | 57207108629 | |
person.identifier.scopus-author-id | 56401521300 | |
person.identifier.scopus-author-id | 55321888200 | |
person.identifier.scopus-author-id | 7003557499 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.embargofct | Os direitos do artigo foram cedidos à revista | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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