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Obesity, energy balance and spermatogenesis

2017Journal article Open access
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dc.contributor.authorOliveira, Pedro F.
dc.contributor.authorSousa, Mário
dc.contributor.authorSilva, Branca M.
dc.contributor.authorMonteiro, Mariana P
dc.contributor.authorAlves, Marco G
dc.date.accessioned2020-02-17T11:11:15Z
dc.date.available2020-02-17T11:11:15Z
dc.date.issued2017
dc.description.abstractObesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and -independent stimuli that control sperm quality. There are conflicting data concerning the impact of male overweight and obesity on sperm quality, as well as on the possible paternal-induced epigenetic trait inheritance of obesity. In addition, it remains a matter of debate whether massive weight loss induced by lifestyle interventions, drugs or bariatric surgery may or may not benefit obese men seeking fatherhood. Herein, we propose to discuss how energy balance may modulate hormonal signalling and sperm quality in overweight and obese men. We also discuss some molecular mechanisms that mediate obesity-related dysfunction in male reproductive system and how paternal obesity may lead to trait inheritance. Finally, we will discuss how lifestyle modifications and sustained weight loss, particularly the loss achieved by bariatric surgery, may revert some of the deleterious effects of obesity in men and their offspring.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1530/REP-17-0018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9280
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationObesitility – Gut hormones and testicular metabolism: mechanisms associated with obesity-related male infertility
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation2014 - Strategic Project
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectObesitypt_PT
dc.subjectSpermatogenesispt_PT
dc.subjectEnergy Metabolismpt_PT
dc.titleObesity, energy balance and spermatogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleObesitility – Gut hormones and testicular metabolism: mechanisms associated with obesity-related male infertility
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitle2014 - Strategic Project
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIM-MET%2F4712%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBBB-BQB%2F1368%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0215%2F2014/PT
oaire.citation.endPageR185pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPageR173pt_PT
oaire.citation.titleReproductionpt_PT
oaire.citation.volume153pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameOliveira
person.familyNameSilva
person.familyNameMonteiro
person.familyNameAlves
person.givenNamePedro Fontes
person.givenNameBranca Maria
person.givenNameMariana
person.givenNameMarco G.
person.identifier2358493
person.identifier1033309
person.identifierR-000-958
person.identifier.ciencia-id9F16-B704-C407
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.ciencia-id4014-C7BC-ED88
person.identifier.ciencia-id7915-53C7-40C2
person.identifier.orcid0000-0002-4989-5699
person.identifier.orcid0000-0002-5610-8024
person.identifier.orcid0000-0002-0662-1831
person.identifier.orcid0000-0001-7635-783X
person.identifier.ridG-4795-2010
person.identifier.scopus-author-id36198848500
person.identifier.scopus-author-id7005615589
person.identifier.scopus-author-id12243571300
person.identifier.scopus-author-id57202054274
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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