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Three New Labdanes Isolated from Eragrostis viscosa

2012-11-01Journal article Restricted access
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dc.contributor.authorSebastião, N'Soki
dc.contributor.authorFernandes, Nelson
dc.contributor.authorVieira, Liliana
dc.contributor.authorMendonça, António
dc.contributor.authorGaspar, Jorge
dc.contributor.authorMartins, Célia
dc.contributor.authorRueff, José
dc.contributor.authorDiakanamwa, Carlos
dc.contributor.authorMendonça, Dina
dc.date.accessioned2022-08-24T09:53:45Z
dc.date.available2022-08-24T09:53:45Z
dc.date.issued2012-11-01
dc.description.abstractThree new labdanes with 8α,15-epoxy ring [methyl 8α,15-epoxylabdan-16β-oate, 8α,15-epoxylabdan-16β-ol and 8α,15-epoxy-16-norlabdan-13β-ol] and five known compounds [8α,15-epoxy-16-norlabdan-13-one, 8α,15-epoxylabdan-16β-oic acid, 3β-(3'',4''-dihydroxy)(E)-cinnamoyloxylup-20(29)-ene, 3-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)β-sitosterol and 16-acetoxy-8α,15-epoxylabdane] were isolated from toluene and dichloromethane extracts of aerial parts of Eragrostis viscosa. The structures of all the compounds were established based on their spectroscopic data and X-ray diffraction analysis of 8α,15-epoxylabdan-16β-ol. It was also studied the genotoxicity of E. viscosa, particularly compounds 16-acetoxy-8α, 15-epoxylabdane, 8α,15-epoxy-16-norlabdan-13-one and 8α, 15-epoxilabdan-16β-ol, using a cytokinesis-block micronucleus assay and the Ames test to assess mutagenicity. Both assays were negative. Cytotoxicity was also analyzed using an MTT assay, and 8α,15-epoxy-16β-ol was shown to be the most cytotoxic of the compounds tested. E. viscosa extracts were also tested to determine their antioxidant capacities, peroxide values and total phenolic contents.pt_PT
dc.description.abstractTrês novos labdanos com anel 8α,15-epoxi [8α,15-epoxilabdan-16β-oato de metila, 8α,15-epoxilabdan-16β-ol e 8α,15-epoxi-16-norlabdan-13β-ol] e cinco compostos conhecidos [8α,15-epoxi-16-norlabdan-13-ona, ácido 8α,15-epoxilabdan-16β-oico, β-(3’’,4’’-di-hidroxi)- (E)-cinamoiloxilup-20(29)-eno, 3-(2’,3’,4’,6’-tetra-O-acetil-β-D-glucopiranosiloxi)-β-sitosterol e 16-acetoxi-8α,15-epoxilabdano] foram isolados dos extratos de tolueno e diclorometano de partes aéreas da Eragrostis viscosa. A estrutura dos compostos foi atribuída a partir dos seus dados espectroscópicos e da análise de difração de raios X do 8α,15-epoxilabdan-16β-ol. Os compostos 16-acetóxi-8α,15-epoxilabdano, 8α,15-epoxi-16-norlabdan-13-ona e 8α,15-epoxilabdan-16β-ol não apresentam genotoxicidade e mutagenicidade, as quais foram avaliadas usando o teste dos micronúcleos e o teste de Ames, respetivamente. A citotoxicidade dos mesmos compostos foi avaliada usando o teste do MTT sendo o 8α,15-epoxilabdan-16β-ol o mais citotóxico de todos os compostos analisados. Foram também avaliadas a capacidade antioxidante, o valor peróxido e o conteúdo em fenóis totais de extratos de E. viscosa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSebastião, N. N., Fernandes, N., Vieira, L., Mendonça, A. J. G., Gaspar, J. F., Martins, C., . . . De Mendonça, D. I.M. (2012). Three new labdanes isolated from eragrostis viscose. Journal of the Brazilian Chemical Society, 23(10), 1940-1950. doi:10.1590/S0103-50532012005000067pt_PT
dc.identifier.doidoi:10.1590/S0103-50532012005000067pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12310
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Brasileira de Químicapt_PT
dc.relationChemical composition of medicinal plants from Angola
dc.relation.ispartofseries10;
dc.subjectEragrostis viscosapt_PT
dc.subject8α,15-epoxylabdanespt_PT
dc.subjectMutagenic activitypt_PT
dc.subjectCytotoxic activitypt_PT
dc.subjectGenotoxicitypt_PT
dc.titleThree New Labdanes Isolated from Eragrostis viscosapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemical composition of medicinal plants from Angola
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FQUI%2F39380%2F2001/PT
oaire.citation.endPage1950pt_PT
oaire.citation.startPage1940pt_PT
oaire.citation.titleJournal of the Brazilian Chemical Societypt_PT
oaire.citation.volume23pt_PT
oaire.fundingStreamPOCI
person.familyNamede Oliveira Vieira
person.familyNameMendonça
person.familyNameRueff
person.familyNameMendonca
person.givenNameLiliana Isabel
person.givenNameAntónio
person.givenNameJosé
person.givenNameDina
person.identifier.ciencia-id5D12-6978-D7B5
person.identifier.ciencia-idDF12-2022-CEC7
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-id0E15-908D-EA21
person.identifier.ciencia-idB112-0768-4411
person.identifier.orcid0000-0001-8747-7642
person.identifier.orcid0000-0002-2759-5935
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0002-8456-7295
person.identifier.orcid0000-0001-9511-2942
person.identifier.ridI-3093-2012
person.identifier.ridAFO-4571-2022
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id6506834578
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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