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Coaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engineering

2017-07-26Journal article Restricted access
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dc.contributor.authorCoimbra, Patrícia
dc.contributor.authorSantos, Patrícia
dc.contributor.authorAlves, Patrícia
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCarvalho, Marco António Paulo de
dc.contributor.authorSá, Kevin
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorFerreira, Paula
dc.date.accessioned2018-03-22T10:13:07Z
dc.date.available2018-03-22T10:13:07Z
dc.date.issued2017-07-26
dc.description.abstractCoaxial electrospinning is a technique that allows the production of nanofibers with a core–shell structure. Such fibers present several advantages as materials for the preparation of scaffolds, namely due to the possibility of combining a core with the desired mechanical properties with a shell prepared from biocompatible materials that will establish proper interactions with the host. Herein, core-shell fibrous meshes, composed of a polycaprolactone (PCL) core and a functionalized gelatin shell, were prepared by coaxial electrospinning and then photocrosslinked under UV light aiming to be used in vascular tissue regeneration. The suitability of the meshes for the pretended biomedical application was evaluated by assessing their chemical/physical properties as well as their haemo and biocompatibility in vitro. The obtained results revealed that meshes’ shell prepared with a higher content of gelatin showed fibers with diameters presenting a unimodal distribution and a mean value of 600 nm. Moreover, those fibers with higher content of gelatin also displayed lower water contact angles, and therefore higher hydrophilicities. Such features are crucial for the good biologic performance displayed by these meshes, when in contact with blood and with Normal Human Dermal Fibroblasts cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citation2.2.4.88. Coimbra, P., Santos, P., Alves, P., Miguel, S. P., Carvalho, M. P., de Sá, K. D., Correia, I. J. e Ferreira, P. (2017). “Coaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engineering.” Colloids and Surfaces B: Biointerfaces, Vol. 159, pp.7-15.pt_PT
dc.identifier.doi10.1016/j.colsurfb.2017.07.065pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4706
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
dc.relationDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
dc.relationPHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0927776517304885#!pt_PT
dc.subjectCoaxial electrospinningpt_PT
dc.subjectPhotocrosslinkingpt_PT
dc.subjectScaffoldspt_PT
dc.subjectTissue engineeringpt_PT
dc.subjectBiocompatibilitypt_PT
dc.titleCoaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
oaire.awardTitleDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
oaire.awardTitlePHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage15pt_PT
oaire.citation.startPage7pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume159pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStreamOE
oaire.fundingStreamPOR_CENTRO
person.familyNameAlmeida Coimbra
person.familyNameAlves
person.familyNamePereira Miguel
person.familyNameSá
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNamePatrícia Manuela
person.givenNamePatrícia
person.givenNameSónia Alexandra
person.givenNameKevin
person.givenNameIlídio
person.givenNamePaula
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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