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Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping

2016-02-17Journal article Restricted access
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dc.contributor.authorFradique, Ricardo Gil
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorSá, Kevin
dc.contributor.authorFigueira, Daniela Sofia Rodrigues
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-21T11:44:43Z
dc.date.available2018-03-21T11:44:43Z
dc.date.issued2016-02-17
dc.description.abstractThe incidence of bone disorders, whether due to trauma or pathology, has been trending upward with the aging of the worldwide population. The currently available treatments for bone injuries are rather limited, involving mainly bone grafts and implants. A particularly promising approach for bone regeneration uses rapid prototyping (RP) technologies to produce 3D scaffolds with highly controlled structure and orientation, based on computer-aided design models or medical data. Herein, tricalcium phosphate (TCP)/alginate scaffolds were produced using RP and subsequently their physicochemical, mechanical and biological properties were characterized. The results showed that 60/40 of TCP and alginate formulation was able to match the compression and present a similar Young modulus to that of trabecular bone while presenting an adequate biocompatibility. Moreover, the biomineralization ability, roughness and macro and microporosity of scaffolds allowed cell anchoring and proliferation at their surface, as well as cell migration to its interior, processes that are fundamental for osteointegration and bone regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFradique R., Correia, T.R., Miguel S.P., Sá K.D., Figueira D.R., Mendonça A.G. e Correia, I.J. (2016) "Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping", Journal of Materials Science Materials in Medicine, Vol.27 (69)pt_PT
dc.identifier.doi10.1007/s10856-016-5681-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4681
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10856-016-5681-x#enumerationpt_PT
dc.subjectAlginatept_PT
dc.subjectSimulated Body Fluidpt_PT
dc.subjectBone Regenerationpt_PT
dc.subjectRapid Prototypept_PT
dc.subjectComposite Scaffoldpt_PT
dc.titleProduction of new 3D scaffolds for bone tissue regeneration by rapid prototypingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.titleJournal of Materials Science: Materials in Medicinept_PT
oaire.citation.volume27pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFradique
person.familyNameCorreia
person.familyNamePereira Miguel
person.familyNameSá
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.givenNameRicardo
person.givenNameTiago
person.givenNameSónia Alexandra
person.givenNameKevin
person.givenNameAntónio
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-6331-2034
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id55797637100
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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