Publication
Sulfobetaine methacrylate-albumin-coated graphene oxide incorporating IR780 for enhanced breast cancer phototherapy
dc.contributor.author | Melo, Bruna L. | |
dc.contributor.author | Sousa, Rita Lima | |
dc.contributor.author | Alves, Cátia | |
dc.contributor.author | Ferreira, Paula | |
dc.contributor.author | Moreira, André | |
dc.contributor.author | Correia, I.J. | |
dc.contributor.author | Diogo, Duarte de Melo | |
dc.date.accessioned | 2021-03-05T11:44:51Z | |
dc.date.available | 2023-03-04T01:30:19Z | |
dc.date.issued | 2021-03-04 | |
dc.description.abstract | Aim: Enhance the colloidal stability and photothermal capacity of graphene oxide (GO) by functionalizing it with sulfobetaine methacrylate (SBMA)-grafted bovine serum albumin (BSA; i.e., SBMA-g-BSA) and by loading IR780, respectively. Materials & methods: SBMA-g-BSA coating and IR780 loading into GO was achieved through a simple sonication process. Results: SBMA-g-BSA-functionalized GO (SBMA-BSA/GO) presented an adequate size distribution and cytocompatibility. When in contact with biologically relevant media, the size of the SBMA-BSA/GO only increased by 8%. By loading IR780 into SBMA-BSA/GO, its photothermal capacity increased by twofold. The combination of near infrared light with SBMA-BSA/GO did not induce photocytotoxicity on breast cancer cells. In contrast, the interaction of IR780-loaded SBMA-BSA/GO with near infrared light caused the ablation of cancer cells. Conclusion: IR780-loaded SBMA-BSA/GO displayed an improved colloidal stability and phototherapeutic capacity. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.2217/nnm-2020-0460 | pt_PT |
dc.identifier.issn | 1743-5889 | |
dc.identifier.uri | http://hdl.handle.net/10400.6/11117 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Future medicine | pt_PT |
dc.relation | Health Sciences Research Centre | |
dc.relation | Development of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer | |
dc.relation | Injectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy | |
dc.subject | 2D materials | pt_PT |
dc.subject | Cancer therapy | pt_PT |
dc.subject | Graphene nanomaterials | pt_PT |
dc.subject | Photothermal therapy | pt_PT |
dc.subject | Zwitterionic coatings | pt_PT |
dc.subject | Protein-based coatings | pt_PT |
dc.title | Sulfobetaine methacrylate-albumin-coated graphene oxide incorporating IR780 for enhanced breast cancer phototherapy | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | Health Sciences Research Centre | |
oaire.awardTitle | Development of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer | |
oaire.awardTitle | Injectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT | |
oaire.citation.conferencePlace | London | pt_PT |
oaire.citation.title | Nanomedicine | pt_PT |
oaire.fundingStream | 6817 - DCRRNI ID | |
oaire.fundingStream | POR_CENTRO | |
oaire.fundingStream | POR_CENTRO | |
person.familyName | Lopes Melo | |
person.familyName | Sousa | |
person.familyName | Alves | |
person.familyName | Cristina Nunes Ferreira Calvinho | |
person.familyName | Moreira | |
person.familyName | Joaquim Sobreira Correia | |
person.familyName | Miguel de Melo Diogo | |
person.givenName | Bruna Daniela | |
person.givenName | Ana Rita Lima | |
person.givenName | Cátia Gomes | |
person.givenName | Paula | |
person.givenName | André Ferreira | |
person.givenName | Ilídio | |
person.givenName | Duarte | |
person.identifier | 1161643 | |
person.identifier | UMbJ1KMAAAAJ | |
person.identifier | C2z5x04AAAAJ | |
person.identifier.ciencia-id | 5717-CB52-B4E5 | |
person.identifier.ciencia-id | BD19-68AA-7099 | |
person.identifier.ciencia-id | 8317-7EF2-24C8 | |
person.identifier.ciencia-id | A119-FFB8-0899 | |
person.identifier.ciencia-id | 4C1E-012B-83CE | |
person.identifier.ciencia-id | F610-7373-DC81 | |
person.identifier.ciencia-id | 9C10-9BD8-634E | |
person.identifier.orcid | 0000-0002-0078-1877 | |
person.identifier.orcid | 0000-0003-4764-1967 | |
person.identifier.orcid | 0000-0001-7066-3051 | |
person.identifier.orcid | 0000-0003-3393-4427 | |
person.identifier.orcid | 0000-0002-0604-2506 | |
person.identifier.orcid | 0000-0003-1613-9675 | |
person.identifier.orcid | 0000-0001-9984-3603 | |
person.identifier.rid | B-1125-2019 | |
person.identifier.scopus-author-id | 57201215315 | |
person.identifier.scopus-author-id | 57201213407 | |
person.identifier.scopus-author-id | 55321888200 | |
person.identifier.scopus-author-id | 56401521300 | |
person.identifier.scopus-author-id | 7003557499 | |
person.identifier.scopus-author-id | 56266511300 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.embargofct | O Copyright foi cedido à revista | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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