Publication
Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
| dc.contributor.author | Gil-Longo, José | |
| dc.contributor.author | Laguna, Maria de los Reyes | |
| dc.contributor.author | Verde, Ignacio | |
| dc.contributor.author | Castro, Elena | |
| dc.contributor.author | Orallo, Francisco | pt |
| dc.contributor.author | Fontenla, Jose A. | |
| dc.contributor.author | Calleja, José Maria | pt |
| dc.contributor.author | Ravina, Enrique | pt |
| dc.contributor.author | Terán, Carmen | |
| dc.date.accessioned | 2010-04-28T10:06:49Z | |
| dc.date.available | 2010-04-28T10:06:49Z | |
| dc.date.issued | 1993 | |
| dc.description.abstract | 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle. | |
| dc.identifier.uri | http://hdl.handle.net/10400.6/558 | |
| dc.language | eng | |
| dc.title | Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 82:286-90 | pt |
| oaire.citation.title | Journal of Pharmaceutical Sciences | pt |
| person.familyName | Gil-Longo | |
| person.familyName | Laguna-Francia | |
| person.familyName | Verde | |
| person.familyName | Castro | |
| person.familyName | Fontenla | |
| person.familyName | Terán | |
| person.givenName | José | |
| person.givenName | Reyes | |
| person.givenName | Ignacio | |
| person.givenName | Elena | |
| person.givenName | Jose A. | |
| person.givenName | Carmen | |
| person.identifier | 2619082 | |
| person.identifier | 1313046 | |
| person.identifier | 184483 | |
| person.identifier.ciencia-id | D012-1D7C-791A | |
| person.identifier.orcid | 0000-0001-7728-7140 | |
| person.identifier.orcid | 0000-0001-7284-6601 | |
| person.identifier.orcid | 0000-0003-3492-5725 | |
| person.identifier.orcid | 0000-0002-6750-5519 | |
| person.identifier.orcid | 0000-0002-9758-676X | |
| person.identifier.orcid | 0000-0003-4377-3604 | |
| person.identifier.rid | M-3991-2013 | |
| person.identifier.rid | K-6876-2014 | |
| person.identifier.rid | H-7131-2015 | |
| person.identifier.scopus-author-id | 7004115114 | |
| person.identifier.scopus-author-id | 55913729400 | |
| person.identifier.scopus-author-id | 7402292272 | |
| person.identifier.scopus-author-id | 7004054862 | |
| person.identifier.scopus-author-id | 55955691500 | |
| rcaap.rights | openAccess | |
| rcaap.type | article | pt |
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