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Thermoresponsive chitosan–agarose hydrogel for skin regeneration

2014-05-02Journal article Restricted access
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dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorRibeiro, MP.
dc.contributor.authorBrancal, Hugo Gonçalo Monteiro Silva Aguiar
dc.contributor.authorCoutinho, Paula Isabel Teixeira Gonçalves
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-20T14:35:04Z
dc.date.available2018-03-20T14:35:04Z
dc.date.issued2014-05-02
dc.description.abstractHealing enhancement and pain control are critical issues on wound management. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan (deacetylation degree 95%) and agarose. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The performance of the hydrogel in the wound healing process was evaluated through in vivo assays, during 21 days. The attained results revealed that hydrogel has a pore size (90–400 μm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 μg/mL of chitosan. The improved healing and the lack of a reactive or a granulomatous inflammatory reaction in skin lesions treated with hydrogel demonstrate its suitability to be used in a near future as a wound dressing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel, S.P., Ribeiro, M.P., Brancal, H., Coutinho, P. e Correia, I.J. (2014) "Thermoresponsive chitosan-agarose hydrogel for skin regeneration", Carbohydrate Polymers, Vol. 111, pp. 366-373pt_PT
dc.identifier.doi10.1016/j.carbpol.2014.04.093pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4658
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 4056 - 2011-2012
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861714004573?via%3Dihubpt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectHydrogelpt_PT
dc.subjectSkin substitutespt_PT
dc.subjectWound healingpt_PT
dc.titleThermoresponsive chitosan–agarose hydrogel for skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 4056 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEGE%2FUI4056%2F2011/PT
oaire.citation.endPage373pt_PT
oaire.citation.startPage366pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume111pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePereira Miguel
person.familyNameRibeiro
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameMaximiano
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3fe7a59f-e867-4bed-bb6e-7d7631330af5
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscovery3956033a-4abf-439b-a4fd-25c5bd9d8e7a
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