Repository logo
 
Publication

Acetylcholinesterase Inhibitory Activity of Extracts from Angolan Medicinal Plants

2015-07-21Journal article Restricted access
Simple item page
dc.contributor.authorFernandes, Nelson
dc.contributor.authorCanelo, Laura
dc.contributor.authorMendonca, Dina
dc.contributor.authorMendonça, António
dc.date.accessioned2018-12-13T16:27:21Z
dc.date.available2018-12-13T16:27:21Z
dc.date.issued2015-07-21
dc.description.abstractPlants are considered important sources of new chemical entities that can be used in the development of novel therapeutic drugs for the symptomatic treatment of Alzheimer’s disease. The inhibition of acetylcholinesterase by 38 extracts from 13 medicinal plants used in Angola folk medicine are presented: Adenodolichos huillensis (roots and leaves); Boscia microphylla (leaves); Croton gratissimus (aerial part); Gymnosporia senegalensis (branches); Hymenodictyon floribundum (barks); Parinari capensis (leaves); Peucedano angolense (aerial part); Phragmanthera glaucocarpa (roots); Rhus kirkii (leaves); Solanecio mannii (branches); Solanum incanum (fruit); Tinnea antiscorbutica (aerial part) and Xylopia odoratissima (leaves). TLC bioautographic assay and Ellman’s method were used. The best results for IC50 were obtained with the toluene extract of B. microphylla leaves (0.55 ± 0.01 mg/mL) and the methanol extract of G. senegalensis branches (0.30 ± 0.00 mg/mL). The aqueous extract of the leaves of P. capensis also demonstrated acetylcholinesterase inhibitory activity in the two methods used. In conclusion, the medicinal plants P. capensis, B. microphylla and G. senegalensis represent promising sources of natural compounds with acetylcholinesterase inhibitory properties.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes, N A F, Canelo, L I N, Mendonça, D I M D de, Mendonça, A J G de.,2015. Acetylcholinesterase Inhibitory Activity of Extracts from Angolan Medicinal Plants. International Journal of Pharmacognosy and Phytochemical Research; 7(4); 768-776pt_PT
dc.identifier.issn0975-4873
dc.identifier.urihttp://hdl.handle.net/10400.6/6612
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDr. Yashwant Research Labs Pvt. Ltdpt_PT
dc.relation.publisherversionhttp://impactfactor.org/PDF/IJPPR/7/IJPPR,Vol7,Issue4,Article26.pdfpt_PT
dc.subjectAlzheimer's diseasept_PT
dc.subjectAcetylcholinesterase inhibitorspt_PT
dc.subjectEllman’s methodpt_PT
dc.subjectTLC bioautographic assaypt_PT
dc.subjectAngola folk medicinept_PT
dc.subjectMedicinal plantspt_PT
dc.titleAcetylcholinesterase Inhibitory Activity of Extracts from Angolan Medicinal Plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.citation.endPage776pt_PT
oaire.citation.startPage768pt_PT
oaire.citation.titleInternational Journal of Pharmacognosy and Phytochemical Researchpt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream5876
person.familyNameMendonca
person.familyNameMendonça
person.givenNameDina
person.givenNameAntónio
person.identifier.ciencia-id5D12-6978-D7B5
person.identifier.ciencia-idB112-0768-4411
person.identifier.ciencia-id2419-6E20-F958
person.identifier.orcid0000-0001-8747-7642
person.identifier.orcid0000-0001-9511-2942
person.identifier.orcid0000-0001-8069-0440
person.identifier.ridAFO-4571-2022
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id6506834578
person.identifier.scopus-author-id56890866600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication380b78e8-b5b2-4685-8e6f-0226966564b6
relation.isAuthorOfPublicationc5ae631b-1ee7-4d88-af70-eda0a565f4b7
relation.isAuthorOfPublicationfbccceb8-2850-4fe1-ae4f-4aeded7bf32a
relation.isAuthorOfPublication.latestForDiscoveryc5ae631b-1ee7-4d88-af70-eda0a565f4b7
relation.isProjectOfPublicationf6d0aa1d-d8a8-4438-b222-023db42ef45e
relation.isProjectOfPublication.latestForDiscoveryf6d0aa1d-d8a8-4438-b222-023db42ef45e

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
IJPPR,Vol7,Issue4,Article26.pdf
Size:
707.64 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ICI - CICS | Documentos por Auto-Depósito
FC - DQ | Documentos por Auto-Depósito
ICI - FibEnTech | Documentos por Auto-Depósito