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Development of gold-core silica shell nanospheres coated with poly-2-ethyl-oxazoline and β-cyclodextrin aimed for cancer therapy

2019-01-16Journal article Restricted access
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dc.contributor.authorReis, Ana Catarina Almeida
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorMoreira, André
dc.contributor.authorJacinto, Telma A.
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-01-17T11:48:38Z
dc.date.available2019-01-17T11:48:38Z
dc.date.issued2019-01-16
dc.description.abstractCancer is one of the major world public health problems and the currently available treatments are nonspecific and ineffective. This reality highlights the importance of developing novel therapeutic approaches. In this field, multifunctional nanomedicines have the potential to revolutionize the currently available treatments. These unique nanodevices can simultaneously act as therapeutic and imaging agents allowing the real-time monitoring of the nanoparticles biodistribution and the treatment outcome. Among the different nanoparticles, the gold-core silica shell (AuMSS) nanoparticles advantageous physicochemical and biological properties make them promising nanoplatforms for cancer therapy. Nevertheless, their successful application as an effective cancer nanomedicine is limited by the unfavorable pharmacokinetics and uncontrolled release of the therapeutic payloads. Herein, a new polymeric coating for AuMSS nanospheres was developed by combining different ratios (25/75, 50/50 and 75/25) of two materials, Poly-2-ethyl-2-oxazoline (PEOZ) and β-cyclodextrin (β-CD). The surface functionalization of AuMSS nanospheres led to a size increase and to the neutralization of the surface charge. On the other side, the nanoparticles biological performance was improved. The coated AuMSS nanospheres showed an increased cytocompatibility and internalization rate by the HeLa cancer cells. Overall, the obtained data confirm the successful modification of the AuMSS nanospheres with PEOZ and β-CD as well as their promising properties for being applied in cancer therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationReis, C.A., Rodrigues, C.F., Moreira, A.F., Jacinto, T.A., Ferreira, P., Correia, I.J. (2019) "Development of Gold-Core Silica Shell Nanospheres Coated with Poly-2-ethyl-oxazoline and ß-cyclodextrin Aimed for Cancer Therapy", Materials Science and Engineering C, in press.pt_PT
dc.identifier.doi10.1016/j.msec.2019.01.068pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6799
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S092849311832424X?via%3Dihubpt_PT
dc.subjectGold nanoparticlesSilicaCancerPoly-2-ethyl-2-oxazolinept_PT
dc.subjectβ-Cyclodextrinpt_PT
dc.subjectSilicapt_PT
dc.subjectCancerpt_PT
dc.subjectPoly-2-ethyl-2-oxazolinept_PT
dc.titleDevelopment of gold-core silica shell nanospheres coated with poly-2-ethyl-oxazoline and β-cyclodextrin aimed for cancer therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameFélix Rodrigues
person.familyNameMoreira
person.familyNameAndrade Jacinto
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Carolina
person.givenNameAndré Ferreira
person.givenNameTelma Maria
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id2717-B57C-9AD7
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-0135-2126
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57205459390
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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