Repository logo
 
Publication

Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin

2017-08-16Journal article Restricted access
Simple item page
dc.contributor.authorVieira, Ana Paula
dc.contributor.authorPimenta, Andreia
dc.contributor.authorSilva, Diana
dc.contributor.authorGil, Maria
dc.contributor.authorAlves, Patrícia
dc.contributor.authorCoimbra, Patrícia
dc.contributor.authorMata, Jose
dc.contributor.authorBozukova, Dimitriya
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorSerro, Ana Paula
dc.contributor.authorGuiomar, António
dc.date.accessioned2018-03-22T10:21:17Z
dc.date.available2018-03-22T10:21:17Z
dc.date.issued2017-08-16
dc.description.abstractEndophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX). Argon plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA) in the presence of MFX was the approach selected for surface modification, with MFX loaded both by entrapment in the grafted polyHEMA coating and by soaking. Surface and bulk properties were evaluated before and after surface modification and the MFX release profiles were obtained both in batch mode (sink conditions) and under hydrodynamic conditions, employing a purpose-built microfluidic cell, which simulated the hydrodynamic conditions around the eye lens. The effect of storage on the release profile of the best system was also assessed. The best system released MFX for ca. 15 days above the minimum inhibitory concentration for Staphylococcus aureus and Staphylococcus epidermidis. The released MFX showed antimicrobial activity against these bacteria and was non-cytotoxic against corneal endothelial cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVieira, A. P., Pimenta, A. F., Silva, D., Gil, M. H., Alves, P., Coimbra, P., Mata, J. L. G. C., Bozukova, D., Correia, T. R., Correia, I.J., Serro, A. P. e Guiomar, A. J. (2017). “Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin.” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 120, pp.52-62.pt_PT
dc.identifier.doi10.1016/j.ejpb.2017.08.006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4707
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSurface modifications to control drug release from therapeutic ophthalmic lenses
dc.relationSterilization of clinically active hydrogels: looking for efficient strategies
dc.relationStrategic Project - UI 100 - 2013-2014
dc.relationHealth Sciences Research Centre
dc.relationDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
dc.relationUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0939641116309237#!pt_PT
dc.subjectCataractpt_PT
dc.subjectEndophthalmitispt_PT
dc.subjectIntraocular lenspt_PT
dc.subjectControlled releasept_PT
dc.subjectMoxifloxacinpt_PT
dc.subjectPlasma graftingpt_PT
dc.subjectArgonpt_PT
dc.subject2-hydroxyethyl methacrylatept_PT
dc.titleSurface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSurface modifications to control drug release from therapeutic ophthalmic lenses
oaire.awardTitleSterilization of clinically active hydrogels: looking for efficient strategies
oaire.awardTitleStrategic Project - UI 100 - 2013-2014
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
oaire.awardTitleUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0006%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-BIO%2F3640%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PT
oaire.citation.endPage62pt_PT
oaire.citation.startPage52pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume120pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNamePimenta
person.familyNameSilva
person.familyNameGil
person.familyNameAlves
person.familyNameAlmeida Coimbra
person.familyNameMata
person.familyNameBozukova
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameValagão Amadeu do Serro
person.familyNameRebelo Ferreira Guiomar
person.givenNameAndreia
person.givenNameDiana
person.givenNameMaria Helena
person.givenNamePatrícia
person.givenNamePatrícia Manuela
person.givenNameJose
person.givenNameDimitriya
person.givenNameTiago
person.givenNameIlídio
person.givenNameAna Paula
person.givenNameAntónio Jorge
person.identifier2068879
person.identifierUMbJ1KMAAAAJ
person.identifierH-7797-2012
person.identifier.ciencia-id191C-D525-9EA5
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id111E-0CE2-0C3E
person.identifier.ciencia-id7A15-7341-1FDC
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idC012-F8B6-A58E
person.identifier.ciencia-id9312-E34E-C90B
person.identifier.orcid0000-0002-9990-4581
person.identifier.orcid0000-0003-0102-7048
person.identifier.orcid0000-0003-0657-7751
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0001-7021-407X
person.identifier.orcid0000-0001-5108-4556
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-6179-9296
person.identifier.ridS-2076-2019
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id57191821317
person.identifier.scopus-author-id56789539900
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id25647116900
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6603259828
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa2c6dfdf-ce46-46f2-8a10-234061249eda
relation.isAuthorOfPublicationf83ebb9c-1d74-4e2d-bd3b-27782b08fb74
relation.isAuthorOfPublication676a8017-743a-4f22-93be-4915428f318d
relation.isAuthorOfPublication64a3aef7-8d91-4327-8407-294909eed51a
relation.isAuthorOfPublication95a46930-ac14-449d-8ddd-db23927062b0
relation.isAuthorOfPublication15816376-3fd1-49f0-9809-8c25d09a79ed
relation.isAuthorOfPublication3a374faa-6f9e-49f2-b1bb-6af70e2cdeaf
relation.isAuthorOfPublicationafa2836e-3210-4320-9c63-0b52828e043a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication02edea7c-61f6-4acd-9539-ac43ae44cfdf
relation.isAuthorOfPublication3ef06c47-679e-4a84-9c65-25fa81ae6258
relation.isAuthorOfPublication.latestForDiscovery676a8017-743a-4f22-93be-4915428f318d
relation.isProjectOfPublication833df203-a8ed-4efc-b505-db40c53313e1
relation.isProjectOfPublication9658f94d-49c4-4b84-bd14-a9074da3bea2
relation.isProjectOfPublicationf5a98512-8027-4414-b31a-eb61db017395
relation.isProjectOfPublication4fbaf6cc-cc34-4641-a856-9cc9793cc856
relation.isProjectOfPublication1bea56d9-b91c-42af-a6d6-8004792eaac0
relation.isProjectOfPublication32509dd2-26d9-4c7c-ad3d-5f30dbc6124e
relation.isProjectOfPublicationeb51c023-622d-4ecf-8177-f197f71ce004
relation.isProjectOfPublication.latestForDiscovery833df203-a8ed-4efc-b505-db40c53313e1

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2017 Vieira EJPB.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito