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Polyurea dendrimer for efficient cytosolic siRNA delivery

2014-10-07Journal article Restricted access
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dc.contributor.authorRestani, Rita
dc.contributor.authorConde, João
dc.contributor.authorBaptista, Pedro
dc.contributor.authorCidade, Maria Teresa Varanda
dc.contributor.authorBragança, Ana
dc.contributor.authorMorgado, Jorge
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.contributor.authorBonifácio, Vasco
dc.date.accessioned2018-03-20T15:06:01Z
dc.date.available2018-03-20T15:06:01Z
dc.date.issued2014-10-07
dc.description.abstractThe design of small interfering RNA (siRNA) delivery materials showing efficacy in vivo is at the forefront of nanotherapeutics research. Polyurea (PURE-type) dendrimers are ‘smart’ biocompatible 3D polymers that unveil a dynamic and elegant back-folding mechanism involving hydrogen bonding between primary amines at the surface and tertiary amines and ureas at the core. Similarly, to a biological proton pump, they are able to automatically and reversibly transform their conformation in response to pH stimulus. Here, we show that PURE-G4 is a useful gene silencing platform showing no cellular toxicity. As a proof of concept we investigated the PURE-G4-siRNA dendriplex, which was shown to be an attractive platform with high transfection efficacy. The simplicity associated with the complexation of siRNA with polyurea dendrimers makes them a powerful tool for efficient cytosolic siRNA delivery.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRestani, R.B., Conde, J., Baptista, P.V., Cidade, M.T., Bragança, A.M., Morgado, J., Correia, I.J., Aguiar-Ricardo, A. e Bonifácio, V.D.B. (2014) “Polyurea dendrimer for efficient cytosolic siRNA delivery”, RSC Advances, Vol. 4(97): pp. 54872-54878pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4663
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relation2013 - Strategic Project
dc.relation2014 - Strategic Project
dc.relation2013 - Strategic Project
dc.relationSmart porous particles for pulmonary drug and vaccine delivery
dc.relationSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
dc.relationJust in Time Dendrimers
dc.relationGREEN SYNTHESIS OF FUNCTIONAL POLYMER MICRODEVICES
dc.relationCANCER THERAGNOSTICS - MULTIFUNCTIONAL GOLD NANOPARTICLES FOR DIAGNOSTICS AND THERAPY
dc.subjectSiRNApt_PT
dc.subjectDendrimerpt_PT
dc.subjectPolyureapt_PT
dc.titlePolyurea dendrimer for efficient cytosolic siRNA deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle2013 - Strategic Project
oaire.awardTitle2014 - Strategic Project
oaire.awardTitle2013 - Strategic Project
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery
oaire.awardTitleSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
oaire.awardTitleJust in Time Dendrimers
oaire.awardTitleGREEN SYNTHESIS OF FUNCTIONAL POLYMER MICRODEVICES
oaire.awardTitleCANCER THERAGNOSTICS - MULTIFUNCTIONAL GOLD NANOPARTICLES FOR DIAGNOSTICS AND THERAPY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FCTM%2FLA0025%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0009%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F116097%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-NAN%2F1812%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM%2F099452%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F66858%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F62957%2F2009/PT
oaire.citation.endPage54878pt_PT
oaire.citation.startPage54872pt_PT
oaire.citation.titleBonifáciopt_PT
oaire.citation.volume4pt_PT
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person.familyNameConde
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.familyNameBonifácio
person.givenNameJoão
person.givenNameIlídio
person.givenNameAna
person.givenNameVasco Daniel Bigas
person.identifierF-2231-2011
person.identifierUMbJ1KMAAAAJ
person.identifier239073
person.identifierbit.ly/google_scholar_bonifacio
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.orcid0000-0001-8422-6792
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.orcid0000-0003-2349-8473
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id56992468300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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