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Strategies to improve the photothermal capacity of gold-based nanomedicines

2020-09-07Journal article Open access
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dc.contributor.authorGonçalves, Ariana S.C.
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-09-22T14:22:00Z
dc.date.available2022-09-22T00:30:20Z
dc.date.issued2020-09-07
dc.description.abstractThe plasmonic photothermal properties of gold nanoparticles have been widely explored in the biomedical field to mediate a photothermal effect in response to the irradiation with an external light source. Particularly, in cancer therapy, the physicochemical properties of gold-based nanomaterials allow them to efficiently accumulate in the tumor tissue and then mediate the light-triggered thermal destruction of cancer cells with high spatial-temporal control. Nevertheless, the gold nanomaterials can be produced with different shapes, sizes, and organizations such as nanospheres, nanorods, nanocages, nanoshells, and nanoclusters. These gold nanostructures will present different plasmonic photothermal properties that can impact cancer thermal ablation. This review analyses the application of gold-based nanomaterials in cancer photothermal therapy, emphasizing the main parameters that affect its light-to-heat conversion efficiency and consequently the photothermal potential. The different shapes/organizations (clusters, shells, rods, stars, cages) of gold nanomaterials and the parameters that can be fine-tuned to improve the photothermal capacity are presented. Moreover, the gold nanostructures combination with other materials (e.g. silica, graphene, and iron oxide) or small molecules (e.g. indocyanine green and IR780) to improve the nanomaterials photothermal capacity is also overviewed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.actbio.2020.09.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10446
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.subjectGold nanoparticlespt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectCancerpt_PT
dc.subjectNIR radiationpt_PT
dc.titleStrategies to improve the photothermal capacity of gold-based nanomedicinespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.titleActa Biomaterialiapt_PT
oaire.fundingStream5876
person.familyNameFélix Rodrigues
person.familyNameMoreira
person.familyNameCorreia
person.givenNameAna Carolina
person.givenNameAndré Ferreira
person.givenNameIlídio Joaquim Sobreira
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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