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Biomaterials for drug delivery patches

2018-03-20Journal article Restricted access
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dc.contributor.authorSantos, Lúcia
dc.contributor.authorCorreia, I.J.
dc.contributor.authorSilva, A. Sofia
dc.contributor.authorMano, João
dc.date.accessioned2018-03-22T10:41:21Z
dc.date.available2018-03-22T10:41:21Z
dc.date.issued2018-03-20
dc.description.abstractThe limited efficiency of conventional drugs has been instigated the development of new and more effective drug delivery systems (DDS). Transdermal DDS, are associated with numerous advantages such its painless application and less frequent replacement and greater flexibility of dosing, features that triggered the research and development of such devices. Such systems have been produced using either biopolymer; or synthetic polymers. Although the first ones are safer, biocompatible and present a controlled degradation by human enzymes or water, the second ones are the most currently available in the market due to their greater mechanical resistance and flexibility, and non-degradation over time. This review highlights the most recent advances (mainly in the last five years) of patches aimed for transdermal drug delivery, focusing on the different materials (natural, synthetic and blends) and latest designs for the development of such devices, emphasizing also their combination with drug carriers that enable enhanced drug solubility and a more controlled release of the drug over the time. The benefits and limitations of different patches formulations are considered with reference to their appliance to transdermal drug delivery. Furthermore, a record of the currently available patches on the market is given, featuring their most relevant characteristics. Finally, a list of most recent/ongoing clinical trials regarding the use of patches for skin disorders is detailed and critical insights on the current state of patches for transdermal drug delivery are also provided.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, L.F., Correia, I.J., Silva, A.S., Mano, J.F. (2018) “Biomaterials for drug delivery patches”, European Journal of Pharmaceutical Sciences, Vol. 118, pp.49-66pt_PT
dc.identifier.doi10.1016/j.ejps.2018.03.020pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4709
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCICECO-Aveiro Institute of Materials
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928098718301350pt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectTransdermal deliverypt_PT
dc.subjectPatchespt_PT
dc.subjectPolymerspt_PT
dc.subjectSkinpt_PT
dc.subjectDrug carrierspt_PT
dc.titleBiomaterials for drug delivery patchespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F50011%2F2013/PT
oaire.citation.endPage49pt_PT
oaire.citation.issue66pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutical Sciencespt_PT
oaire.citation.volume118pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameJoaquim Sobreira Correia
person.familyNameMatias da Silva
person.givenNameIlídio
person.givenNameAna Sofia
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id7A1A-FEC8-7940
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-5388-1732
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationd520a5a3-94a9-4b6d-ae60-4f7b1b2e4b71
relation.isAuthorOfPublication.latestForDiscoveryd520a5a3-94a9-4b6d-ae60-4f7b1b2e4b71
relation.isProjectOfPublication995efa60-0703-4a5f-b427-3cb4cb883743
relation.isProjectOfPublication.latestForDiscovery995efa60-0703-4a5f-b427-3cb4cb883743

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