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Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging

2015-01-07Journal article Restricted access
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dc.contributor.authorSilva, A. Sofia
dc.contributor.authorBonifácio, Vasco
dc.contributor.authorRaje, Vivek
dc.contributor.authorBranco, Paula S.
dc.contributor.authorMachado, Paulo Filipe Brito
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-20T16:05:43Z
dc.date.available2018-03-20T16:05:43Z
dc.date.issued2015-01-07
dc.description.abstractGold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching and a careful design must be carried out to maintain optoelectronic properties and biocompatibility. In this work, the synthesis of fluorescent gold nanoprobes, able to enter the cell's environment (biotags) and target the cell nucleus, was designed and the particles tracked by confocal laser scanning microscopy. The coating of AuNPs with maleimide poly(ethylene glycol) and fluorescent oligoaziridine biocompatible oligomers, resulted in robust, optically active biotags that open novel insights into cancer theragnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A.S., Bonifácio, V.D.B., Raje, V.P., Branco, P., Machado, P., Correia, I.J. e Aguiar-Ricardo A. (2015) “Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging”, RSC Advances, Vol. 5(14), pp. 10733-10738pt_PT
dc.identifier.doi10.1039/C4RA15743Ept_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4667
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relation2013 - Strategic Project
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationAEROSOLIZED GOLD-NANODEVICES FOR THERANOSTIC LUNG DELIVERY
dc.relation.publisherversionhttp://pubs.rsc.org/en/content/articlelanding/2015/ra/c4ra15743e#!divAbstractpt_PT
dc.subjectPEGpt_PT
dc.subjectNanogoldpt_PT
dc.subjectOligoaziridinept_PT
dc.titleDesign of oligoaziridine-PEG coatings for efficient nanogold cellular biotaggingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle2013 - Strategic Project
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleAEROSOLIZED GOLD-NANODEVICES FOR THERANOSTIC LUNG DELIVERY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F51584%2F2011/PT
oaire.citation.endPage10738pt_PT
oaire.citation.startPage10733pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume5pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream5876-PPCDTI
person.familyNameMatias da Silva
person.familyNameBonifácio
person.familyNameBranco
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.givenNameAna Sofia
person.givenNameVasco Daniel Bigas
person.givenNamePaula Cristina de Sério
person.givenNameIlídio
person.givenNameAna
person.identifierbit.ly/google_scholar_bonifacio
person.identifierUMbJ1KMAAAAJ
person.identifier239073
person.identifier.ciencia-id7A1A-FEC8-7940
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.ciencia-id3D12-0B91-9DD0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-5388-1732
person.identifier.orcid0000-0003-2349-8473
person.identifier.orcid0000-0002-7312-8596
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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