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Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review

2021-01-30Journal article Open access
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dc.contributor.authorGraça, Mariana F. P.
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorCorreia, I.J.
dc.contributor.authorMoreira, André
dc.date.accessioned2021-02-22T09:54:44Z
dc.date.available2021-02-22T09:54:44Z
dc.date.issued2021-01-30
dc.description.abstractDespite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, asymmetric membranes emerged as a promising solution since they reproduce both epidermal and dermal skin layers. Wet or dry/wet phase inversion, scCO2-assisted phase inversion, and electrospinning have been the most used techniques to produce such a type of membranes. Among them, the electrospinning technique, due to its versatility, allows the development of multifunctional dressings, using natural and/or synthetic polymers, which resemble the extracellular matrix of native skin as well as address the specific requirements of each skin layer. Moreover, various therapeutic or antimicrobial agents have been loaded within nanofibers to further improve the wound healing performance of these membranes. This review article provides an overview of the application of asymmetric electrospun membranes as wound dressings displaying antibacterial activity and as delivery systems of biomolecules that act as wound healing enhancers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/pharmaceutics13020183pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11110
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAsymmetric membranespt_PT
dc.subjectBioactive moleculespt_PT
dc.subjectElectrospun membranespt_PT
dc.subjectSkin regenerationpt_PT
dc.subjectWound dressingpt_PT
dc.titleElectrospun Asymmetric Membranes as Promising Wound Dressings: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePais Graça
person.familyNameMiguel de Melo Diogo
person.familyNameJoaquim Sobreira Correia
person.familyNameMoreira
person.givenNameMariana Filipa
person.givenNameDuarte
person.givenNameIlídio
person.givenNameAndré Ferreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier1161643
person.identifier.ciencia-id611F-B0F7-2C15
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.orcid0000-0001-7891-6041
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0604-2506
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56401521300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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