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Combinatorial delivery of doxorubicin and acridine orange by gold core silica shell nanospheres functionalized with poly(ethylene glycol) and 4- methoxybenzamide for cancer targeted therapy

2021-03-20Journal article Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorFernandes, Natanael
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.contributor.authorMoreira, André F.
dc.date.accessioned2021-03-22T08:48:12Z
dc.date.available2023-03-20T01:31:40Z
dc.date.issued2021-03-20
dc.description.abstractCombinatorial therapies based on the simultaneous administration of multiple drugs can lead to synergistic effects, increasing the efficacy of the cancer therapy. However, it is crucial to develop new delivery systems that can increase the drugs' therapeutic selectivity and efficacy. Gold core silica shell (AuMSS) nanoparticles present physicochemical properties that allow their simultaneous application as drug delivery and imaging agents. Herein, poly(ethylene glycol) was modified with 4-methoxybenzamide and 3- (triethoxysilyl)propyl isocyanate (TPANIS) to create a novel surface functionalization capable of improving the colloidal stability and specificity of AuMSS nanospheres towards cancer cells. Moreover, a dual drug combination based on Doxorubicin (DOX) and Acridine orange (AO) was characterized and administered using the AuMSS-TPANIS nanospheres. The obtained results show that the DOX:AO drug combination can mediate a synergistic therapeutic effect in both HeLa and MCF-7 cells, particularly at the 2:1, 1:1, and 1:2 ratios. Otherwise, the TPANIS functionalization increased the AuMSS nanospheres colloidal stability and selectivity towards MCF-7 cancer cells (overexpressing sigma receptors). Such also resulted in an enhanced cytotoxic effect against MCF-7 cells when administering the DOX:AO drug combination with the AuMSSTPANIS nanospheres. Overall, the obtained results confirm the therapeutic potential of the DOX:AO drug combination as well as the targeting capacity of AuMSS-TPANIS, supporting its application in the cancer targeted combinatorial chemotherapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.jinorgbio.2021.111433pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11119
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.subjectCancerpt_PT
dc.subjectDrug Combinationpt_PT
dc.subjectAcridine orangept_PT
dc.subjectDoxorubicinpt_PT
dc.subjectGold core silica shell nanoparticlespt_PT
dc.subjectPEGpt_PT
dc.subjectAnisamidept_PT
dc.titleCombinatorial delivery of doxorubicin and acridine orange by gold core silica shell nanospheres functionalized with poly(ethylene glycol) and 4- methoxybenzamide for cancer targeted therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.titleJournal of Inorganic Biochemistrypt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGuimarães
person.familyNameFélix Rodrigues
person.familyNameFernandes
person.familyNameMiguel de Melo Diogo
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameJoaquim Sobreira Correia
person.familyNameMoreira
person.givenNameRafaela
person.givenNameAna Carolina
person.givenNameNatanael
person.givenNameDuarte
person.givenNamePaula
person.givenNameIlídio
person.givenNameAndré Ferreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier1161643
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2315-CC5A-3DBB
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.orcid0000-0002-5340-3650
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-7737-9288
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0604-2506
person.identifier.scopus-author-id57215580577
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56401521300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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