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Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review

2025-04-24Review article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPouso, Manuel António do Rosário
dc.contributor.authorMelo, Bruna Daniela Lopes
dc.contributor.authorGonçalves, Joaquim
dc.contributor.authorLouro, Ricardo
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorde Melo-Diogo, Duarte
dc.date.accessioned2025-10-02T10:50:31Z
dc.date.available2025-10-02T10:50:31Z
dc.date.issued2025-04-24
dc.description.abstractMultiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into nanoparticles can overcome most of the solubility concerns. However, the ability of systemically administered drug-loaded nanomaterials to reach the tumor site has been vastly overestimated, limiting their clinical translation. The drugs’ and drug-loaded nanomaterials’ systemic administration issues have propelled the development of hydrogels capable of performing their direct/local delivery into the tumor site. The use of these macroscale systems to mediate a tumor-confined delivery of the drugs/drugs-loaded nanomaterials grants an improved therapeutic efficacy and, simultaneously, a reduction of the side effects. The manufacture of these hydrogels requires the careful selection and tailoring of specific polymers/materials as well as the choice of appropriate physical and/or chemical crosslinking interactions. Depending on their administration route and assembling process, these matrices can be classified as injectable in situ forming hydrogels, injectable shear-thinning/selfhealing hydrogels, and implantable hydrogels, each type bringing a plethora of advantages for the intended biomedical application. This review provides the reader with an insight into the application of injectable and implantable hydrogels for performing the tumor-confined delivery of drugs and drug-loaded nanomaterials.eng
dc.identifier.citationPouso, M. R., Melo, B. L., Gonçalves, J. J., Louro, R. O., Mendonça, A. G., Correia, I. J., & de Melo-Diogo, D. (2025). Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review. International Journal of Pharmaceutics, 125640
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2025.125640
dc.identifier.issn1873-3476
dc.identifier.urihttp://hdl.handle.net/10400.6/18941
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationHealth Sciences Research Centre
dc.relationCICS-UBI
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
dc.relationAssociate Laboratory of Energy, Transports and Aeronautics UIDP/50022/2020
dc.relation2024.01490.BD
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0378517325004776?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer Therapy
dc.subjectDrug delivery systems
dc.subjectImplantable hydrogels
dc.subjectInjectable hydrogels
dc.subjectLocal chemotherapy
dc.subjectLocal delivery
dc.subjectNanomaterials
dc.titleInjectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A reviewpor
dc.typereview article
dspace.entity.typePublication
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleCICS-UBI
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
oaire.awardTitleAssociate Laboratory of Energy, Transports and Aeronautics UIDP/50022/2020
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F00709%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.06320.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50022%2F2020/PT
oaire.citation.startPage125640
oaire.citation.titleInternational Journal of Pharmaceutics
oaire.citation.volume677
oaire.fundingStreamCEEC IND4ed
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStream3599-PPCDT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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