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Functionalization and photocuring of an L-lactic acid macromer for biomedical applications

2016-04-07Journal article Restricted access
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dc.contributor.authorMarques, Dina
dc.contributor.authorSantos, João
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGil, Maria
dc.contributor.authorBaptista, Cristina Maria dos Santos Gaudêncio
dc.date.accessioned2018-03-21T10:28:43Z
dc.date.available2018-03-21T10:28:43Z
dc.date.issued2016-04-07
dc.description.abstractL-lactic acid was the starting material for obtaining bioahesives. Reaction with 1,4-butanediol provided a telechelic lactic acid prepolymer with hydroxyl end groups further functionalized with 2-isocyanatoethyl methacrylate. Films were produced upon UV irradiation, 2 min, after addition of Irgacure 2959. This was a solvent and catalyst free process. Thermal characterization of films confirmed stability at physiological temperature, enabling photocuring. Adhesion properties were assessed with good results. In vitro degradation tests showed moderate hydrolytic instability dependent on thickness. SEM images revealed a uniform and compact structure. Thrombosis tests confirmed the materials’ thrombogenicity while biocompatibility experiments showed fibroblast viability and antimicrobial behavior.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, D.S., Santos, J.M.C., Ferreira, P., Correia, T.R., Correia, I.J., Gil, M.H. e Baptista, C.M.S.G. (2016) "Functionalization and photocuring of a L-lactic acid macromer for biomedical applications", International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 65, pp.497-507pt_PT
dc.identifier.doi10.1080/00914037.2015.1129962pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4679
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationPREPARAÇÃO E CARACTERIZAÇÃO DE NOVOS MATERIAIS BIODEGRADÁVEIS DE BASE POLIÁCIDO LÁCTICO
dc.relationPHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/00914037.2015.1129962pt_PT
dc.subjectBioadhesivespt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectBiodegradablept_PT
dc.subjectL-lactic acidpt_PT
dc.subjectPhotocuringpt_PT
dc.titleFunctionalization and photocuring of an L-lactic acid macromer for biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePREPARAÇÃO E CARACTERIZAÇÃO DE NOVOS MATERIAIS BIODEGRADÁVEIS DE BASE POLIÁCIDO LÁCTICO
oaire.awardTitlePHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F42245%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F86338%2F2012/PT
oaire.citation.endPage507pt_PT
oaire.citation.startPage497pt_PT
oaire.citation.titleInternational Journal of Polymeric Materials and Polymeric Biomaterialspt_PT
oaire.citation.volume65pt_PT
oaire.fundingStreamOE
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameGil
person.givenNamePaula
person.givenNameTiago
person.givenNameIlídio
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-0657-7751
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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