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STEAP1 is over-expressed in breast cancer and down-regulated by 17β-estradiol in MCF-7 cells and in the rat mammary gland

2008Journal article Restricted access
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dc.contributor.authorMaia, C J
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorSantos, Cecilia
dc.date.accessioned2019-10-08T14:26:23Z
dc.date.available2019-10-08T14:26:23Z
dc.date.issued2008
dc.description.abstractSix transmembrane epithelial antigen of the prostate 1 (STEAP1) was identified as a prostate-specific cell-surface antigen over-expressed in prostate cancer, and in human cancer cell lines obtained from several other tissues. Its cell surface location in all tumor types analyzed so far, and its absence in most vital organs in humans, turned STEAP1 into a potential target for anti-tumor immunotherapy. This study provides experimental evidence that STEAP1 is also over-expressed in human breast cancer cases, and in normal breast tissue adjacent to breast tumors, where it is localized in the cell membrane of epithelial cells. It is also demonstrated that STEAP1 transcription correlates negatively with estrogen receptor (ER) immunoreactivity, and positively with tumor grading in breast cancer cases. As estrogens are involved in breast cancer onset and progression, the response of STEAP1 to 17beta-estradiol (E2) was investigated in the mammary gland of rats, and in the human breast cancer cell line, MCF-7. These experiments demonstrated that STEAP1 is down-regulated by E2 in both models. The mechanisms underlying the STEAP1 response to E2 in vitro were further investigated in MCF-7 cells, and the results obtained suggest an effect mediated by the membrane-bound ERalpha (mbERalpha).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12020-008-9113-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7222
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBreast Cancerpt_PT
dc.subjectGene expressionpt_PT
dc.subjectEstradiolpt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectReal Time PCRpt_PT
dc.subjectSTEAP1pt_PT
dc.titleSTEAP1 is over-expressed in breast cancer and down-regulated by 17β-estradiol in MCF-7 cells and in the rat mammary glandpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage116pt_PT
oaire.citation.issue1-3pt_PT
oaire.citation.startPage108pt_PT
oaire.citation.volume34pt_PT
person.familyNameMaia Baptista
person.familyNameSocorro
person.familyNameSchmitt
person.familyNameSANTOS
person.givenNameCláudio Jorge
person.givenNameSílvia Cristina da Cruz Marques
person.givenNameFernando
person.givenNameCecília Reis Alves
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.ciencia-id761A-7ED2-D68F
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-8181-488X
person.identifier.orcid0000-0003-1006-6946
person.identifier.orcid0000-0001-6074-7825
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id23097994600
person.identifier.scopus-author-id7202545664
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1080c532-c737-4b60-bc44-1d18e3c877d7
relation.isAuthorOfPublication1fb06949-0e6c-41a6-bb25-11885e7f0e9a
relation.isAuthorOfPublication8dd07c9e-eb0d-4e4a-a8d1-2e3787e7f7bf
relation.isAuthorOfPublication21e86061-71ea-4cfa-bc85-0fcd6e847911
relation.isAuthorOfPublication.latestForDiscovery8dd07c9e-eb0d-4e4a-a8d1-2e3787e7f7bf

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