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The Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Common Agent for Overlapping Pathologies

2019Journal article Open access
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dc.contributor.authorSilveira, Ana C.
dc.contributor.authorDias, Jane
dc.contributor.authorSantos, Vanessa M.
dc.contributor.authorOliveira, P.F.
dc.contributor.authorAlves, Marco G
dc.contributor.authorRato, Luís
dc.contributor.authorSilva, Branca M.
dc.date.accessioned2020-02-14T17:25:00Z
dc.date.available2020-02-14T17:25:00Z
dc.date.issued2019
dc.description.abstractDiabetes Mellitus (DM) and Alzheimer's disease (AD) are two prevalent diseases in modern societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has already been demonstrated that these two diseases are associated, since individuals suffering from DM are prone to develop AD. Conversely, it is also known that individuals with AD are more susceptible to DM, namely type 2 diabetes (T2DM). Therefore, these two pathologies, although completely different in terms of symptomatology, end up sharing several mechanisms at the molecular level, with the most obvious being the increase of oxidative stress and inflammation. Polyphenols are natural compounds widely spread in fruits and vegetables whose dietary intake has been considered inversely proportional to the incidence of DM and AD. So, it is believed that this group of phytochemicals may have preventive and therapeutic potential, not only by reducing the risk and delaying the development of these pathologies, but also by improving brain's metabolic profile and cognitive function. The aim of this review is to understand the extent to which DM and AD are related pathologies, the degree of similarity and the relationship between them, to detail the molecular mechanisms by which polyphenols may exert a protective effect, such as antioxidant and anti-inflammatory effects, and highlight possible advantages of their use as common preventive and therapeutic alternatives.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1570159X16666180803162059pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9278
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAlzheimer Diseasept_PT
dc.subjectAnimalspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectDiabetes Mellitus Type 2pt_PT
dc.subjectHumanspt_PT
dc.subjectInflammationpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectPolyphenolspt_PT
dc.titleThe Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Common Agent for Overlapping Pathologiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage613pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage590pt_PT
oaire.citation.titleCurrent Neuropharmacologypt_PT
oaire.citation.volume17pt_PT
person.familyNamePires dos Santos Dias
person.familyNameOliveira
person.familyNameAlves
person.familyNameSilva
person.givenNameJane Risete
person.givenNamePedro Fontes
person.givenNameMarco G.
person.givenNameBranca Maria
person.identifier2358493
person.identifier1033309
person.identifier.ciencia-id9711-2291-CC80
person.identifier.ciencia-id9F16-B704-C407
person.identifier.ciencia-id7915-53C7-40C2
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.orcid0000-0002-1721-6073
person.identifier.orcid0000-0002-4989-5699
person.identifier.orcid0000-0001-7635-783X
person.identifier.orcid0000-0002-5610-8024
person.identifier.ridG-4795-2010
person.identifier.scopus-author-id36198848500
person.identifier.scopus-author-id57202054274
person.identifier.scopus-author-id7005615589
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd69a1528-1f39-4f66-bdee-57df9f31e9bf
relation.isAuthorOfPublicationaf92f693-46e2-4ecb-a719-526b41ab6735
relation.isAuthorOfPublication594afd9f-82a9-4580-a801-05ca4137950e
relation.isAuthorOfPublication2c14722e-0257-4c40-ae19-9e71df94ab4f
relation.isAuthorOfPublication.latestForDiscovery2c14722e-0257-4c40-ae19-9e71df94ab4f

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