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Bioactive polymeric–ceramic hybrid 3D scaffold for application in bone tissue regeneration

2013-07-13Journal article Restricted access
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dc.contributor.authorTorres, Ana
dc.contributor.authorGaspar, V. M.
dc.contributor.authorSerra, Inês Raquel Tavares
dc.contributor.authorCarlos, Gabriela Soares Diogo
dc.contributor.authorFradique, Ricardo Gil
dc.contributor.authorSilva, Abílio P.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-03-20T09:53:56Z
dc.date.available2018-03-20T09:53:56Z
dc.date.issued2013-07-13
dc.description.abstractThe regeneration of large bone defects remains a challenging scenario from a therapeutic point of view. In fact, the currently available bone substitutes are often limited by poor tissue integration and severe host inflammatory responses, which eventually lead to surgical removal. In an attempt to address these issues, herein we evaluated the importance of alginate incorporation in the production of improved and tunable β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) three-dimensional (3D) porous scaffolds to be used as temporary templates for bone regeneration. Different bioceramic combinations were tested in order to investigate optimal scaffold architectures. Additionally, 3D β-TCP/HA vacuum-coated with alginate, presented improved compressive strength, fracture toughness and Young's modulus, to values similar to those of native bone. The hybrid 3D polymeric–bioceramic scaffolds also supported osteoblast adhesion, maturation and proliferation, as demonstrated by fluorescence microscopy. To the best of our knowledge this is the first time that a 3D scaffold produced with this combination of biomaterials is described. Altogether, our results emphasize that this hybrid scaffold presents promising characteristics for its future application in bone regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTorres, A.L., Gaspar, V.M., Serra, I.R., Diogo, G.S., Fradique, R., Silva, A.P. e Correia, I.J. (2013) "Bioactive Polymeric-Ceramic Hybrid 3D Scaffold for Application in Bone Tissue Regeneration", Materials Science & Engineering C - Materials for Biological Applications, Vol. 33(7), pp. 4460-4469pt_PT
dc.identifier.doi10.1016/j.msec.2013.07.003pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4646
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relationBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928493113004062pt_PT
dc.subject3D scaffoldspt_PT
dc.subjectBioceramicspt_PT
dc.subjectBone regenerationpt_PT
dc.subjectFoam replication methodpt_PT
dc.subjectVacuum coatingpt_PT
dc.titleBioactive polymeric–ceramic hybrid 3D scaffold for application in bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitleBIOSYNTHESIS AND PURIFICATION OF MINICIRCLE DNA FOR APPLICATION IN DIABETES CELL-SPECIFIC GENE THERAPY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-TME%2F103375%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
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oaire.citation.endPage4469pt_PT
oaire.citation.startPage4460pt_PT
oaire.citation.titleMaterials Science and Engineering Cpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameGaspar
person.familyNameDiogo
person.familyNameFradique
person.familyNameSilva
person.familyNameJoaquim Sobreira Correia
person.givenNameVítor
person.givenNameGabriela
person.givenNameRicardo
person.givenNameAbilio
person.givenNameIlídio
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id6F16-3640-73E3
person.identifier.ciencia-idD314-9C94-0B0F
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0372-2493
person.identifier.orcid0000-0002-5696-631X
person.identifier.orcid0000-0001-6331-2034
person.identifier.orcid0000-0002-2100-7223
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1602-2017
person.identifier.ridO-1474-2013
person.identifier.scopus-author-id36968590900
person.identifier.scopus-author-id55797637100
person.identifier.scopus-author-id8540933900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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