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Preparation of functionalized poly(caprolactone diol)/castor oils blends to be applied as photocrosslinkable tissue adhesives

2020-02-10Journal article Open access
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dc.contributor.authorCernadas, Maria Teresa
dc.contributor.authorMorgado, Stacy
dc.contributor.authorAlves, Patrícia
dc.contributor.authorGonçalves, Filipa A. M. M.
dc.contributor.authorCorreia, T.R.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorFerreira, Paula
dc.date.accessioned2020-03-04T12:07:07Z
dc.date.available2022-03-08T01:30:17Z
dc.date.issued2020-02-10
dc.description.abstractPolycaprolactone (PCL) and PCL-based materials are widely applied in the biomedical field, however, their slow biodegradation profile makes them more suitable to be used in hard tissues, where healing requires longer periods of time. In order to adjust their properties to suit for soft tissues applications, PCL can be blended with other biodegradable materials in order to tune its degradation rate. Herein, polymeric blends of PCL and castor oil (CO) were prepared after their chemical modification with 2-isocyanatoethylmethacrylate (IEMA) in order to be applied as photocrosslinkable tissue adhesives. These functionalized macromers were chemically characterized and used to prepare polymeric blends (PCL-IEMA/CO-IEMA) with variable mass proportions. A biocompatible photoinitiator (Irgacure 2959) was added to these macromers blends which were then irradiated under UV light. The feasibility of the prepared materials as tissue adhesives was evaluated by assessment of their chemical/physical properties as well as their interaction with blood. Moreover, their cytotoxic profile was also evaluated through in vitro studies using human dermal fibroblasts as model cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1002/app.49092pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9713
dc.language.isoengpt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/app.49092pt_PT
dc.subjectBioadhesivept_PT
dc.subjectFunctionalizationpt_PT
dc.subjectPhotocrosslinkingpt_PT
dc.subjectPolymeric blendpt_PT
dc.titlePreparation of functionalized poly(caprolactone diol)/castor oils blends to be applied as photocrosslinkable tissue adhesivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.conferencePlaceEUApt_PT
oaire.citation.startPage49092pt_PT
oaire.citation.titleJournal of Applied Polymer Sciencept_PT
oaire.fundingStream5876
person.familyNameCernadas
person.familyNameAlves
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNameMaria Teresa
person.givenNamePatrícia
person.givenNameTiago
person.givenNameIlídio
person.givenNamePaula
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8C1C-0ED0-BDA6
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0003-2704-7290
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright do artigo foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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