Publication
Red blood cell membrane-camouflaged gold-core silica shell nanorods for cancer drug delivery and photothermal therapy
| dc.contributor.author | Rodrigues, Ana Carolina F. | |
| dc.contributor.author | Correia, I.J. | |
| dc.contributor.author | Moreira, André F. | |
| dc.date.accessioned | 2024-03-25T15:10:25Z | |
| dc.date.available | 2024-03-25T15:10:25Z | |
| dc.date.issued | 2024-03-15 | |
| dc.description.abstract | Gold core mesoporous silica shell (AuMSS) nanorods are multifunctional nanomedicines that can act simultaneously as photothermal, drug delivery, and bioimaging agents. Nevertheless, it is reported that once administrated, nanoparticles can be coated with blood proteins, forming a protein corona, that directly impacts on nanomedicines’ circulation time, biodistribution, and therapeutic performance. Therefore, it become crucial to develop novel alternatives to improve nanoparticles’ half-life in the bloodstream. In this work, Polyethylenimine (PEI) and Red blood cells (RBC)-derived membranes were combined for the first time to functionalize AuMSS nanorods and simultaneously load acridine orange (AO). The obtained results revealed that the RBC 41 derived membranes promoted the neutralization of the AuMSS’ surface charge and consequently improved the colloidal stability and biocompatibility of the nanocarriers. Indeed, the in vitro data revealed that PEI/RBC-derived membranes’ functionalization also improved the nanoparticles’ cellular internalization and was capable of mitigating the hemolytic effects of AuMSS and AuMSS/PEI nanorods. In turn, the combinatorial chemo-photothermal therapy mediated by AuMSS/PEI/RBC_AO nanorods was able to completely eliminate HeLa cells, contrasting with the less efficient standalone therapies. Such data reinforce the potential of AuMSS nanomaterials to act simultaneously as photothermal and chemotherapeutic agents. | pt_PT |
| dc.description.version | info:eu-repo/semantics/acceptedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.ijpharm.2024.124007 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.6/14319 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Silk Sericin as an industrial wastewater with valuable biomedical potential | |
| dc.relation | Development of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer | |
| dc.relation | Associate Laboratory of Energy, Transports and Aeronautics | |
| dc.relation | Associate Laboratory of Energy, Transports and Aeronautics | |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378517324002412 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Cancer | pt_PT |
| dc.subject | Drug delivery | pt_PT |
| dc.subject | Gold core silica shell nanorods | pt_PT |
| dc.subject | Photothermal therapy | pt_PT |
| dc.subject | PEI | pt_PT |
| dc.subject | RBC-derived membranes | pt_PT |
| dc.title | Red blood cell membrane-camouflaged gold-core silica shell nanorods for cancer drug delivery and photothermal therapy | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Silk Sericin as an industrial wastewater with valuable biomedical potential | |
| oaire.awardTitle | Development of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer | |
| oaire.awardTitle | Associate Laboratory of Energy, Transports and Aeronautics | |
| oaire.awardTitle | Associate Laboratory of Energy, Transports and Aeronautics | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.06320.PTDC/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50022%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50022%2F2020/PT | |
| oaire.citation.conferencePlace | Holanda | pt_PT |
| oaire.citation.startPage | 124007 | pt_PT |
| oaire.citation.title | International Journal of Pharmaceutics | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Félix Rodrigues | |
| person.familyName | Joaquim Sobreira Correia | |
| person.familyName | Moreira | |
| person.givenName | Ana Carolina | |
| person.givenName | Ilídio | |
| person.givenName | André Ferreira | |
| person.identifier | UMbJ1KMAAAAJ | |
| person.identifier | 1161643 | |
| person.identifier.ciencia-id | 3D14-BE84-E5CD | |
| person.identifier.ciencia-id | F610-7373-DC81 | |
| person.identifier.ciencia-id | 4C1E-012B-83CE | |
| person.identifier.orcid | 0000-0002-5493-8331 | |
| person.identifier.orcid | 0000-0003-1613-9675 | |
| person.identifier.orcid | 0000-0002-0604-2506 | |
| person.identifier.scopus-author-id | 57202076016 | |
| person.identifier.scopus-author-id | 7003557499 | |
| person.identifier.scopus-author-id | 56401521300 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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