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Poly(vinyl alcohol)/chitosan asymmetrical membranes: Highly controlled morphology toward the ideal wound dressing

2014-06-24Journal article Restricted access
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dc.contributor.authorMorgado, Patrícia I.
dc.contributor.authorLisboa, Pedro
dc.contributor.authorRibeiro, MP.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorSimões, Pedro
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-20T14:47:34Z
dc.date.available2018-03-20T14:47:34Z
dc.date.issued2014-06-24
dc.description.abstractAsymmetrical membranes have been reported as ideal wound dressings for skin regeneration. The usual methods (dry/wet-phase inversion) to produce those specific membranes are time consuming, and in majority of the cases demand the use of harmful organic solvents. In this study, supercritical carbon dioxide (scCO2)-assisted phase inversion method was applied to prepare poly(vinyl alcohol)/chitosan (PVA/CS) asymmetrical membranes. This technique can tailor the final structure of the dressing by tuning the processing conditions allowing the development of high porous materials with optimized morphology, mechanical properties and hydrophilicity. The PVA/CS dressings produced are recovered in a dry state but can form a hydrogel due to their high water uptake ability maintaining the moisturized environment needed for wound healing. The dressing presents a top thin layer of about 15 µm that allows gaseous exchange while barricading the penetration of microorganisms, and a sponge bottom layer that is able to remove excess exudates. A mathematical model based on Fick׳s second law of diffusion was developed to describe the pharmacokinetic release profile of a small drug (ibuprofen) from the swollen membrane in physiological conditions that mimic the wound. In vitro studies revealed that the dressings had excellent biocompatibility and biodegradation properties adequate for skin wound healing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorgado, P.I., Lisboa, P.F., Ribeiro, M.P., Miguel, S.P., Simões, P.C., Correia, I.J. e Aguiar-Ricardo A. (2014) "Poly(vinyl alcohol)/chitosan asymmetric membranes: highly controlled morphology toward the ideal wound dressing", Journal of Membrane Science, Vol. 469, pp. 262-271pt_PT
dc.identifier.doi10.1016/j.memsci.2014.06.035pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4660
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation2013 - Strategic Project
dc.relationDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
dc.relationVALORIZAÇÃO DE MATÉRIAS-PRIMAS ASSOCIADOS AO PROCESSAMENTO DO CAFÉ POR TECNOLOGIA SUPERCRITICA
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0376738814004864#!pt_PT
dc.subjectSupercritical CO2pt_PT
dc.subjectPhase inversionpt_PT
dc.subjectAsymmetrical membranespt_PT
dc.subjectMathematical modelingpt_PT
dc.subjectWound dressingspt_PT
dc.titlePoly(vinyl alcohol)/chitosan asymmetrical membranes: Highly controlled morphology toward the ideal wound dressingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle2013 - Strategic Project
oaire.awardTitleDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
oaire.awardTitleVALORIZAÇÃO DE MATÉRIAS-PRIMAS ASSOCIADOS AO PROCESSAMENTO DO CAFÉ POR TECNOLOGIA SUPERCRITICA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F80648%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F51890%2F2012/PT
oaire.citation.endPage271pt_PT
oaire.citation.startPage262pt_PT
oaire.citation.titleJournal of Membrane Sciencept_PT
oaire.citation.volume469pt_PT
oaire.fundingStream6820 - DCRRNI ID
person.familyNameDa Cruz Morgado Ferreira
person.familyNameRibeiro
person.familyNamePereira Miguel
person.familyNameSimões
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.givenNamePatrícia Isabel
person.givenNameMaximiano
person.givenNameSónia Alexandra
person.givenNamePedro
person.givenNameIlídio
person.givenNameAna
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person.identifier239073
person.identifier.ciencia-idE71C-3D0E-821B
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person.identifier.ciencia-id6414-46A3-D071
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-1005-9853
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-5295-8905
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridD-5061-2011
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id57197816863
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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