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Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering

2016-05-13Journal article Restricted access
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dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorFerreira, Paula
dc.contributor.authorVaz, Rita
dc.contributor.authorAlves, Patrícia
dc.contributor.authorFigueiredo, Margarida
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorCoimbra, Patrícia
dc.date.accessioned2018-03-21T12:16:21Z
dc.date.available2018-03-21T12:16:21Z
dc.date.issued2016-05-13
dc.description.abstractCardiovascular disease is the leading cause of morbidity and mortality among industrialized countries. Vascular grafts are often required for the surgical treatments. Considering the limitations associated with the use of autografts and with the currently available synthetic materials, a growing demand in tissue engineered vascular grafts has been registered. During the work here described, electrospinning technique was used to prepared fibrous matrices to be applied as vascular implants. For that purpose, electrospun polycaprolactone (PCL) fibrous mats were produced and afterwards coated with different hydrogel formulations based in photocrosslinkable gelatin (GelMA) and the macromers poly(ethylene glycol) acrylate (PEGA) and poly(ethylene glycol) diacrylate (PEGDA). These were further photocrosslinked under UV irradiation using Irgacure® 2959 (by BASF) as the photoinitiator. The suitability of the coated scaffolds for the intended application, was evaluated by assessing their chemical/physical properties as well as their interaction with blood and endothelial cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCorreia, T. R., Ferreira, P., Vaz, R., Alves, P., Figueiredo, M. M., Correia, I. J., e Coimbra, P. (2016) “Development of UV cross-linked gelatin coated electrospun poly (caprolactone) fibrous scaffolds for tissue engineering.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1539-1548pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2016.05.045pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4684
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
dc.relationDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
dc.relationPHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813016304561#!pt_PT
dc.subjectPhotocrosslinkingpt_PT
dc.subjectScaffoldspt_PT
dc.subjectGelatinpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectElectrospinningpt_PT
dc.titleDevelopment of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
oaire.awardTitleDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
oaire.awardTitlePHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F86338%2F2012/PT
oaire.citation.endPage1548pt_PT
oaire.citation.startPage1539pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStreamOE
person.familyNameCorreia
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameAlves
person.familyNameJoaquim Sobreira Correia
person.familyNameAlmeida Coimbra
person.givenNameTiago
person.givenNamePaula
person.givenNamePatrícia
person.givenNameIlídio
person.givenNamePatrícia Manuela
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person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id111E-0CE2-0C3E
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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