Repository logo
 
Publication

Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery

2020-03-06Journal article Open access
Simple item page
dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-05-11T09:29:28Z
dc.date.available2021-06-10T00:30:14Z
dc.date.issued2020-03-06
dc.description.abstractThe application of nanomaterials is regarded nowadays as a highly promising approach for overcoming the limitations of the currently available cancer treatments, contributing for the creation of more effective, precise, and safer therapies. In the last years, organosilica nanoparticles arisen as alternatives to the most common mesoporous silica nanoparticles. The organosilica nanoparticles combine the advantages of the mesoporous silica, such as structural stability and mesoporous structure, with the increased biocompatibility and biodegradability of organic materials. Therefore, the variety of organic bridges that can be incorporated into the silica matrix allowed the development of new and exciting compositions, properties, and functions for improving the therapeutic effectiveness of the anticancer nanomedicines. In this review, the strategies that have been explored to create stimuli-responsive organosilica-based drug delivery systems are highlighted, describing the practical approaches and mechanisms controlling the drug release. Additionally, the organosilica nanoparticles surface modifications aimed for increasing the blood circulation time and the tumor targeting are also described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.phrs.2020.104742pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10283
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.subjectMesoporous organosilica nanoparticlespt_PT
dc.subjectDrug deliverypt_PT
dc.subjectCancer therapypt_PT
dc.subjectNanomedicinept_PT
dc.subjectStimuli responsivept_PT
dc.titleOverview of stimuli-responsive mesoporous organosilica nanocarriers for drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage104742pt_PT
oaire.citation.titlePharmacological Researchpt_PT
oaire.citation.volume155pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameGuimarães
person.familyNameFélix Rodrigues
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameRafaela
person.givenNameAna Carolina
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5340-3650
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57215580577
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdf00b2d7-d512-44b3-afe2-dad4b791a894
relation.isAuthorOfPublication5c78ad01-afa8-470c-b674-0892eeed6534
relation.isAuthorOfPublicatione20bf724-86f1-4fc8-800d-39ff19b624b1
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscovery5c78ad01-afa8-470c-b674-0892eeed6534
relation.isProjectOfPublicationcb4688cf-40da-4197-9eb0-c55bad699ad3
relation.isProjectOfPublicationaf6b5d57-b2b5-4241-bd65-d80fb27f7e9a
relation.isProjectOfPublication5b76944e-3750-4bb4-8eee-0105aa9d6f3f
relation.isProjectOfPublication.latestForDiscoverycb4688cf-40da-4197-9eb0-c55bad699ad3

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2020 Guimarães PR.pdf
Size:
7.33 MB
Format:
Adobe Portable Document Format
Download

Collections

FCS - DCM | Documentos por Auto-Depósito