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Screening of the Potential Bioactivities of Pennyroyal (Mentha pulegium L.) Essential Oil

2021Journal article Open access
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dc.contributor.authorLuís, Ângelo
dc.contributor.authorDomingues, F. C.
dc.date.accessioned2021-11-08T10:15:33Z
dc.date.available2021-11-08T10:15:33Z
dc.date.issued2021
dc.description.abstractIncreasing resistance of pathogens towards conventional antibiotics presents a major threat to public health because it reduces the effectiveness of antibiotic treatment. Mentha pulegium L., also known as pennyroyal, is an aromatic herb that belongs to the family Lamiaceae. Its essential oil has been traditionally used in medicine, aromatherapy, and cosmetics. The purpose of this work was to study the chemical composition of a pennyroyal essential oil and to evaluate their bioactivities, specifically, antioxidant, antimicrobial, anti-quorum sensing, and anti-inflammatory. A special focus was given to the antibacterial activity of the essential oil against Acinetobacter baumannii. The chemical composition of the essential oil was studied by GC-MS/GC-FID. The DPPH free radical scavenging assay and the β-carotene/linoleic acid system were used to evaluate the antioxidant properties. The antimicrobial and anti-quorum sensing activities were evaluated by disk diffusion assays and complemented with optical microscopy observations. The results showed that pulegone was the major compound (88.64%) of the pennyroyal essential oil. Regarding the antimicrobial activity, the action against Acinetobacter baumannii stands out, which, together with the capacity of the essential oil to inhibit the quorum sensing mechanisms, may suggest the use of the pennyroyal essential oil to further develop surface disinfectants for hospitals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/antibiotics10101266pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11245
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPennyroyalpt_PT
dc.subjectMentha pulegiumpt_PT
dc.subjectPulegonept_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAcinetobacter baumanniipt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectQuorum sensingpt_PT
dc.subjectAnti-inflammatorypt_PT
dc.titleScreening of the Potential Bioactivities of Pennyroyal (Mentha pulegium L.) Essential Oilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1266pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSantos Luís
person.familyNameDomingues
person.givenNameÂngelo Filipe
person.givenNameFernanda
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-id6514-0498-3E8F
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-9540-0853
person.identifier.ridN-7295-2013
person.identifier.scopus-author-id10139481400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa2d7c872-99db-41e1-9bc9-82c2d47b4661
relation.isAuthorOfPublication8d5fe6e2-21af-4557-9c46-84103254a18a
relation.isAuthorOfPublication.latestForDiscovery8d5fe6e2-21af-4557-9c46-84103254a18a
relation.isProjectOfPublicationc7cee677-067c-47b2-ab19-b2dd5b0fda9d
relation.isProjectOfPublication.latestForDiscoveryc7cee677-067c-47b2-ab19-b2dd5b0fda9d

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