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Polymeric Nanofibers for Biomedical and Biotechnologic Applications

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dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-04-13T09:13:41Z
dc.date.available2018-04-13T09:13:41Z
dc.date.issued2014
dc.description.abstractBone tissue is a complex structure with the capacity to self-regenerate and responsible for different functions in our body. However, when bone integrity is disturbed, its self-regenerative capacity is lost. The available treatments are based on bone grafts and other bone substitutes which possess several limitations. Herein, a new approach to mimic the extracellular matrix of bone and cellular microenvironment was developed in this work. Therefore, an electrospinning apparatus was used to produce poly(ε-caprolactone), polyethylene oxide-sodium alginate and poly(vinyl)pirrolidone nanofibers. Subsequently, the same procedure was used for coating the alginate scaffold. In addition, poly(ε-caprolactone) electrospun nanofiber membranes were also produced and evaluated for phase separation applications. Membranes specific properties, such as pore size, fibers diameter and surface interactions were studied. The biological properties of the coated scaffolds were evaluated through in vitro cytotoxicity assays. The results showed that all the coated scaffolds had their biological performance improved. The membranes showed to be good candidates for phase separation area.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCorreia, T.R. e Correia, I.J., (2014) “Polymeric Nanofibers for Biomedical and Biotechnologic Applications”, LAP LAMBERT Academic Publishing.pt_PT
dc.identifier.isbn978-3-659-59718-3
dc.identifier.urihttp://hdl.handle.net/10400.6/4737
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherLambert Academic Publishingpt_PT
dc.relation.publisherversionhttps://www.lap-publishing.com/catalog/details/store/pt/book/978-3-659-59718-3/polymeric-nanofibers-for-biomedical-and-biotechnologic-applications?search=365959718xpt_PT
dc.subjectNanofiberspt_PT
dc.subjectPolymerspt_PT
dc.titlePolymeric Nanofibers for Biomedical and Biotechnologic Applicationspt_PT
dc.typebook
dspace.entity.typePublication
person.familyNameCorreia
person.familyNameCorreia
person.givenNameTiago
person.givenNameIlídio Joaquim Sobreira
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typebookpt_PT
relation.isAuthorOfPublicationafa2836e-3210-4320-9c63-0b52828e043a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscoveryf2c3e779-34a2-4309-950a-80687664c6ad

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