In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy

Figueiredo, André Q.; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Correia, I.J.; Moreira, André F.

Publication

In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy

2023-09-08Journal article

dc.contributor.author	Figueiredo, André Q.
dc.contributor.author	Rodrigues, Ana Carolina Félix
dc.contributor.author	Fernandes, Natanael
dc.contributor.author	Correia, I.J.
dc.contributor.author	Moreira, André F.
dc.date.accessioned	2023-12-18T15:20:17Z
dc.date.embargo	2026-12-18
dc.date.issued	2023-09-08
dc.description.abstract	Gold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid nanohybrids (Au-Alg-NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au-Alg-NHs present a uniform size distribution and a spike-like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of ≈11°C in response to the irradiation with a near-infrared region (NIR) laser (808 nm, 1.7 W cm−2). The in vitro assays showed that Au-Alg-NHs were able to perform a NIR light-triggered ablation of cancer cells (MCF-7), being observed a reduction in the cell viability to ≈27%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au-Alg-NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy.	pt_PT
dc.description.sponsorship	Foundation for Science and Technology, Grant/Award Numbers: SFRH/BD/144680/2019,2022.14608.BD,UIDB/00709/2020;EuropeanRegionalDevelopmentFund,Grant/AwardNumbers:CENTRO-01-0145-FEDER-028989,POCI-01-0145-FEDER-031462	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.doi	10.1002/biot.202300019	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.6/13834
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Wiley	pt_PT
dc.relation	Health Sciences Research Centre
dc.relation	Development of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.relation	Development of Gold Core Silica Shell nanomedicines with bioinspired coatings for the immune/photothermal therapy of breast cancer
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Phototermal therapy	pt_PT
dc.subject	Gold nanohybrids	pt_PT
dc.subject	Cancer	pt_PT
dc.subject	Alginic acid	pt_PT
dc.title	In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Health Sciences Research Centre
oaire.awardTitle	Development of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardTitle	Development of Gold Core Silica Shell nanomedicines with bioinspired coatings for the immune/photothermal therapy of breast cancer
oaire.awardURI	info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/POR_CENTRO/2022.14608.BD/PT
oaire.citation.title	Biotechnology Journal	pt_PT
oaire.fundingStream	6817 - DCRRNI ID
oaire.fundingStream	POR_CENTRO
person.familyName	Figueiredo
person.familyName	Félix Rodrigues
person.familyName	Fernandes
person.familyName	Joaquim Sobreira Correia
person.familyName	Moreira
person.givenName	André Filipe Quelhas
person.givenName	Ana Carolina
person.givenName	Natanael
person.givenName	Ilídio
person.givenName	André Ferreira
person.identifier	UMbJ1KMAAAAJ
person.identifier	1161643
person.identifier.ciencia-id	141C-A5C2-BBEC
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person.identifier.ciencia-id	2315-CC5A-3DBB
person.identifier.ciencia-id	F610-7373-DC81
person.identifier.ciencia-id	4C1E-012B-83CE
person.identifier.orcid	0000-0002-5493-8331
person.identifier.orcid	0000-0002-7737-9288
person.identifier.orcid	0000-0003-1613-9675
person.identifier.orcid	0000-0002-0604-2506
person.identifier.scopus-author-id	57202076016
person.identifier.scopus-author-id	7003557499
person.identifier.scopus-author-id	56401521300
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.embargofct	O copyright foi cedido à editora	pt_PT
rcaap.rights	embargoedAccess	pt_PT
rcaap.type	article	pt_PT
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