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Photocurable bioadhesive based on lactic acid

2016-01-01Journal article Restricted access
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dc.contributor.authorMarques, Dina
dc.contributor.authorSantos, João
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGil, Maria
dc.contributor.authorBaptista, Cristina Maria dos Santos Gaudêncio
dc.date.accessioned2018-03-21T10:39:42Z
dc.date.available2018-03-21T10:39:42Z
dc.date.issued2016-01-01
dc.description.abstractNovel photocurable and low molecular weight oligomers based on l-lactic acid with proven interest to be used as bioadhesive were successfully manufactured. Preparation of lactic acid oligomers with methacrylic end functionalizations was carried out in the absence of catalyst or solvents by self-esterification in two reaction steps: telechelic lactic acid oligomerization with OH end groups and further functionalization with methacrylic anhydride. The final adhesive composition was achieved by the addition of a reported biocompatible photoinitiator (Irgacure® 2959). Preliminary in vitro biodegradability was investigated by hydrolytic degradation in PBS (pH = 7.4) at 37 °C. The adhesion performance was evaluated using glued aminated substrates (gelatine pieces) subjected to pull-to-break test. Surface energy measured by contact angles is lower than the reported values of the skin and blood. The absence of cytoxicity was evaluated using human fibroblasts. A notable antimicrobial behaviour was observed using two bacterial models (Staphylococcus aureus and Escherichia coli). The cured material exhibited a strong thrombogenic character when placed in contact with blood, which can be predicted as a haemostatic effect for bleeding control. This novel material was subjected to an extensive characterization showing great potential for bioadhesive or other biomedical applications where biodegradable and biocompatible photocurable materials are required.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, D.S., Santos, J.M.C., Ferreira, P., Correia, T.R., Correia, I.J., Gil, M.H. e Baptista, C.M.S.G. (2016) "Photocurable Bioadhesive Based on Lactic Acid", Materials Science & Engineering C - Materials for Biological Applications, Vol. 58, pp. 601-609pt_PT
dc.identifier.doi10.1016/j.msec.2015.09.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4680
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPREPARAÇÃO E CARACTERIZAÇÃO DE NOVOS MATERIAIS BIODEGRADÁVEIS DE BASE POLIÁCIDO LÁCTICO
dc.relationPHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928493115303337?via%3Dihub#!pt_PT
dc.subjectBioadhesive formulationpt_PT
dc.subjectTelechelic lactic acid prepolymerspt_PT
dc.subjectPhotocurablept_PT
dc.subjectPolycondensationpt_PT
dc.subjectBiocompatibilitypt_PT
dc.titlePhotocurable bioadhesive based on lactic acidpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePREPARAÇÃO E CARACTERIZAÇÃO DE NOVOS MATERIAIS BIODEGRADÁVEIS DE BASE POLIÁCIDO LÁCTICO
oaire.awardTitlePHARMACOLOGICALLY ACTIVE BIOADHESIVE DESIGNED FOR WOUND CLOSURE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F42245%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F86338%2F2012/PT
oaire.citation.endPage609pt_PT
oaire.citation.startPage601pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume58pt_PT
oaire.fundingStreamOE
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameGil
person.givenNamePaula
person.givenNameTiago
person.givenNameIlídio
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-0657-7751
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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