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Effects of platelet-activating-factor on contractions and 45Ca2+ influx induced by noradrenaline and potassium in rat rubbed and intact aorta - comparison with its hypotensive effect in anesthetized normotensive rats
| dc.contributor.author | Verde, Ignacio | |
| dc.contributor.author | Orallo, Francisco | pt |
| dc.contributor.author | Loza, Isabel | pt |
| dc.contributor.author | Alzueta, A. F. | pt |
| dc.contributor.author | Campos,Manuel | pt |
| dc.contributor.author | Freire-Garabal, Manuel | pt |
| dc.date.accessioned | 2010-04-28T10:06:47Z | |
| dc.date.available | 2010-04-28T10:06:47Z | |
| dc.date.issued | 1992 | |
| dc.description.abstract | In order to clarify the mechanism of hypotensive activity of platelet activating factor (PAF), the effects of this drug on blood pressure in anaesthetized normotensive rats, on KCl- and noradrenaline-induced 45Ca uptake and contractile responses in rat aorta rings with and without endothelium were studied. PAF (3 micrograms kg-1, i.v.) showed long-lasting hypotensive effects in anaesthetized normotensive rats accompanied by a significant increase in heart rate. PAF (0.1-10 microM) did not relax the contractions induced by noradrenaline (10 microM) or K+ (60 mM) in rubbed or intact rat aorta. PAF did not affect the basal uptake of 45Ca2+ nor that induced by the two vasoconstrictor agents. In experiments in a calcium free medium, PAF (10 microM) had no effect on the noradrenaline- (10 microM) induced contractions. These results suggest that the hypotensive activity of PAF in normotensive anaesthetized rats is not due to a direct effect on rubbed and intact rat aorta rings (acting within the cell or blocking Ca2+ influx through L-type transmembrane calcium channels). | |
| dc.identifier.uri | http://hdl.handle.net/10400.6/548 | |
| dc.language.iso | eng | pt |
| dc.title | Effects of platelet-activating-factor on contractions and 45Ca2+ influx induced by noradrenaline and potassium in rat rubbed and intact aorta - comparison with its hypotensive effect in anesthetized normotensive rats | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 44:344-8 | pt |
| oaire.citation.title | Journal of Pharmacy and Pharmacology | pt |
| person.familyName | Verde | |
| person.givenName | Ignacio | |
| person.identifier.ciencia-id | D012-1D7C-791A | |
| person.identifier.orcid | 0000-0003-3492-5725 | |
| person.identifier.rid | M-3991-2013 | |
| person.identifier.scopus-author-id | 55913729400 | |
| rcaap.rights | openAccess | pt |
| rcaap.type | article | pt |
| relation.isAuthorOfPublication | bfb58284-b817-4267-9628-8fa150aa681c | |
| relation.isAuthorOfPublication.latestForDiscovery | bfb58284-b817-4267-9628-8fa150aa681c |
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