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VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameters

2017Journal article Open access
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dc.contributor.authorMesquita, Joana
dc.contributor.authorSousa, João Paulo Castro De
dc.contributor.authorPereira, Sara Vaz
dc.contributor.authorNeves, Arminda
dc.contributor.authorRatado, Paulo
dc.contributor.authorSantos, F.M.
dc.contributor.authorPassarinha, LA
dc.contributor.authorTomaz, C. T.
dc.date.accessioned2020-02-11T17:28:03Z
dc.date.available2020-02-11T17:28:03Z
dc.date.issued2017
dc.description.abstractVascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples (n = 33) from diabetic (n = 25) and non-diabetic (n = 8) patients. Results were compared between groups. Optical coherence tomography from diabetic patients was evaluated for central retinal thickness (CRT) and macular volume (MV). Mean vitreous VEGF-B concentration was higher in diabetic (18.82 ± 1.44 pg/mL ) vs. non-diabetic patients (17.90 ± 0.32 pg/mL) (p = 0.006), and in proliferative diabetic retinopathy (PDR) (19.03 ± 1.52 pg/mL) vs. non-PDR (NPDR) patients (18.18 ±0.96 pg/mL) (p = 0.025). In diabetic retinopathy (DR) patients, correlation between VEGF-B and CRT (μm) was positive and moderate: rs = 0.441 (p ≤ 0.05) and the correlation between VEGF-B and MV (mm³) was positive and robust: rs = 0.716 (p ≤ 0.01). VEGF-B levels are overexpressed in vitreous of diabetic patients, and the levels are higher in developed stages of DR. Correlation results show that CRT and MV increase with increased levels of VEGF-B. Targeting VEGF-B inhibition may have therapeutic beneficial implications.pt_PT
dc.description.sponsorshipCENTRO-07-ST24-FEDER-002014)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/medsci5030017pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9222
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationVitreous humor biomarkers in Age-related Macular Degeneration
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAngiogenesispt_PT
dc.subjectDiabetic retinopathypt_PT
dc.subjectEnzyme-linked immunosorbent assaypt_PT
dc.subjectVascular endothelial growth factor-Bpt_PT
dc.subjectVEGF inhibitionpt_PT
dc.subjectVitreous humorpt_PT
dc.titleVEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameterspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVitreous humor biomarkers in Age-related Macular Degeneration
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F112526%2F2015/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage17pt_PT
oaire.citation.titleMedical Sciencespt_PT
oaire.citation.volume5pt_PT
oaire.fundingStreamPOR_CENTRO
person.familyNameMesquita
person.familyNameCastro de Sousa
person.familyNameVaz-Pereira
person.familyNameRatado
person.familyNameMilhano dos Santos
person.familyNamePaulino Passarinha
person.familyNameTomaz
person.givenNameJoana
person.givenNameJoão Paulo
person.givenNameSara
person.givenNamePaulo
person.givenNameFátima Raquel
person.givenNameLuís António
person.givenNameCândida
person.identifierhttps://www.researchgate.net/profile/Luis_Passarinha
person.identifier2198714
person.identifier.ciencia-idD81B-D3DE-23D2
person.identifier.ciencia-idD01A-2666-0E20
person.identifier.ciencia-id621B-74BF-F9A7
person.identifier.ciencia-idFE13-0C44-13D1
person.identifier.orcid0000-0003-0667-0809
person.identifier.orcid0000-0002-0025-1841
person.identifier.orcid0000-0001-6125-5486
person.identifier.orcid0000-0002-5976-0181
person.identifier.orcid0000-0002-4041-1504
person.identifier.orcid0000-0001-6910-7576
person.identifier.orcid0000-0002-0927-2331
person.identifier.ridP-8249-2017
person.identifier.ridF-9367-2014
person.identifier.scopus-author-id56262249200
person.identifier.scopus-author-id55820663800
person.identifier.scopus-author-id24399749400
person.identifier.scopus-author-id12445439600
person.identifier.scopus-author-id7004546303
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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