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Sweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolism

2019Journal article Restricted access
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dc.contributor.authorSilva, Gonçalo
dc.contributor.authorVaz, CV
dc.contributor.authorCatalão, Beatriz
dc.contributor.authorFerreira, Susana
dc.contributor.authorCardoso, HJ
dc.contributor.authorDuarte, A. P.
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2020-01-29T12:00:35Z
dc.date.available2020-01-29T12:00:35Z
dc.date.issued2019
dc.description.abstractThe present work evaluated the anticancer properties of sweet cherry (Prunus avium) extract on human prostate cells. Several sweet cherry cultivars from Fundão (Portugal) were methanol-extracted and their phytochemical composition characterized. The Saco "late harvest" extract was highly-enriched in anthocyanins and selected for use in biological assays. Non-neoplastic (PNT1A) and neoplastic (LNCaP and PC3) human prostate cells were treated with 0-2,000 μg/ml of extract for 48-96 h. Cell viability was evaluated by the MTT assay. Apoptosis, oxidative stress, and glycolytic metabolism were assessed by Western blotting and enzymatic assays. Glucose consumption and lactate production were measured spectrophotometrically. Saco cherry extract diminished the viability of neoplastic and non-neoplastic cells, whereas enhancing apoptosis in LNCaP. Cherry extract-treatment also diminished oxidative damage and suppressed glycolytic metabolism in LNCaP cells. These findings widened the knowledge on the mechanisms by which cherry extract modulate cell physiology, demonstrating their broad action over the hallmarks of cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/01635581.2019.1661502pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8881
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationAndrogens/anti-androgens and glycaemia in reprogramming metabolism of prostate cancer: targeting both androgen receptor and metabolism as a therapeutic option
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/01635581.2019.1661502?journalCode=hnuc20pt_PT
dc.titleSweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAndrogens/anti-androgens and glycaemia in reprogramming metabolism of prostate cancer: targeting both androgen receptor and metabolism as a therapeutic option
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F111351%2F2015/PT
oaire.citation.endPage15pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNutrition and Cancerpt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameSilva
person.familyNameVaz
person.familyNameFerreira
person.familyNameCardoso
person.familyNameDuarte
person.familyNameSocorro
person.givenNameGonçalo
person.givenNameCátia
person.givenNameSusana
person.givenNameHenrique
person.givenNameAna Paula
person.givenNameSílvia Cristina da Cruz Marques
person.identifier1255684
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id1C1D-F91F-D937
person.identifier.ciencia-idF718-3569-E911
person.identifier.ciencia-id1B13-C5B8-72F8
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-1252-2709
person.identifier.orcid0000-0002-7720-4234
person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0002-5750-2875
person.identifier.orcid0000-0003-3333-5977
person.identifier.orcid0000-0001-8181-488X
person.identifier.ridA-6810-2016
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id34874668400
person.identifier.scopus-author-id56421799300
person.identifier.scopus-author-id7102602131
person.identifier.scopus-author-id23097994600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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