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Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives

2019-05-11Journal article Open access
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dc.contributor.authorCernadas, Maria Teresa
dc.contributor.authorGonçalves, Filipa A.M.M.
dc.contributor.authorAlves, P.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCabral, C.S.D.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorFerreira, Paula
dc.date.accessioned2019-05-29T13:35:02Z
dc.date.available2021-05-22T00:30:12Z
dc.date.issued2019-05-11
dc.description.abstractThe study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers composed of unsaturated polyesters (UP) and lactic acid oligomers functionalized with 2-isocyanatoethyl methacrylate (IEMA) were produced. Henceforth, three different stoichiometric proportions were tested, which, after the addition of a biocompatible photoinitiator (Irgacure® 2959), resulted in flexible, resistant and uniform matrices after 2 minutes and 30 seconds of crosslinking. The synthesized materials were then further characterized in terms of chemical composition and thermal/mechanical behaviour. The gel content, dynamic contact angles, water sorption capacity and hydrolytic degradation were also assessed. The biocompatibility and antibacterial activity of the produced materials was also evaluated. Taking into account all the data obtained, it may be concluded that the new synthesized biodegradable bioadhesives present promising properties to be used as surgical adhesives.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.eurpolymj.2019.05.019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7097
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.subjectSurgical adhesivept_PT
dc.subjectPolyesterpt_PT
dc.subjectPhotocrosslinkable copolymerspt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectBiodegradabilitypt_PT
dc.titlePreparation of biodegradable functionalized polyesters aimed to be used as surgical adhesivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01432%2F2015%2FCP1314%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.titleEuropean Polymer Journalpt_PT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameCernadas
person.familyNameGonçalves
person.familyNameAlves
person.familyNamePereira Miguel
person.familyNameCabral
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNameMaria Teresa
person.givenNameFilipa
person.givenNamePatrícia
person.givenNameSónia Alexandra
person.givenNameCátia Solange Duarte
person.givenNameIlídio
person.givenNamePaula
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person.identifier.ciencia-idBB1E-AC11-4CE3
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0003-2704-7290
person.identifier.orcid0000-0001-7035-8161
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id57209992210
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctDireitos de autor cedidos à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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