Repository logo
 
Publication

Natural melanin: A potential pH-responsive drug release device

2014-04-23Journal article Restricted access
Simple item page
dc.contributor.authorAraújo, Marco
dc.contributor.authorViveiros, Raquel
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorBonifácio, Vasco
dc.contributor.authorCasimiro, Teresa
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-20T10:32:39Z
dc.date.available2018-03-20T10:32:39Z
dc.date.issued2014-04-23
dc.description.abstractThis work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality, the application of this biopolymer in the pharmaceutical and biomedical fields is yet to be explored. Herein, melanin nanoparticles were impregnated with metronidazole, chosen as model antibiotic drug, using supercritical carbon dioxide. The drug release profile was investigated at acidic and physiologic pH, and the dominant mechanism was found to follow a non-Fickian transport. Drug release from melanin shows a strong pH dependency, which allied to its biocompatibility and lack of cytotoxicity envisages its potential application as nanocarrier in formulations for colon and intestine targeted drug delivery.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2014.04.051pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4648
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationJust in Time Dendrimers
dc.relationSmart porous particles for pulmonary drug and vaccine delivery
dc.relation2013 - Strategic Project
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517314002877#!pt_PT
dc.subjectMelaninpt_PT
dc.subjectPH-responsive drug releasept_PT
dc.subjectNanocarrierpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.titleNatural melanin: A potential pH-responsive drug release devicept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleJust in Time Dendrimers
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery
oaire.awardTitle2013 - Strategic Project
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QUI%2F102460%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM%2F099452%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F116097%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.citation.endPage145pt_PT
oaire.citation.startPage140pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume469pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6820 - DCRRNI ID
person.familyNameAraujo
person.familyNameViveiros
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameBonifácio
person.familyNameCasimiro
person.familyNameAguiar-Ricardo
person.givenNameMarco
person.givenNameRaquel
person.givenNameTiago
person.givenNameIlídio
person.givenNameVasco Daniel Bigas
person.givenNameTeresa
person.givenNameAna
person.identifierO-3129-2015
person.identifierUMbJ1KMAAAAJ
person.identifierbit.ly/google_scholar_bonifacio
person.identifier239073
person.identifier.ciencia-idF512-C284-6399
person.identifier.ciencia-id5E1F-6619-2E27
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.ciencia-idC319-27F6-1C6B
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-3997-6209
person.identifier.orcid0000-0002-0449-2343
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-2349-8473
person.identifier.orcid0000-0001-9405-6221
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id7202962455
person.identifier.scopus-author-id36182047900
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e498dad-704e-44e5-868b-5594cd265527
relation.isAuthorOfPublication09e18151-430b-4bb3-a1d5-df7b438731b2
relation.isAuthorOfPublicationafa2836e-3210-4320-9c63-0b52828e043a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication25a08d6b-f1f6-43e2-b59c-eb82fad34ef8
relation.isAuthorOfPublication851fdb4e-afc8-44e5-895b-26beaf4f8234
relation.isAuthorOfPublication11660e51-cb00-4f75-8ca1-274d0c47c590
relation.isAuthorOfPublication.latestForDiscoveryf2c3e779-34a2-4309-950a-80687664c6ad
relation.isProjectOfPublication0c12d6c7-67d5-4b8d-8854-f674da399b19
relation.isProjectOfPublication28c79848-0cf6-4068-81c7-b79dddddf757
relation.isProjectOfPublication49b7bf99-eb69-4301-a72f-3f11286ea606
relation.isProjectOfPublicationb8a4479b-0d43-4cb3-8860-54a0f2b75c7c
relation.isProjectOfPublication.latestForDiscovery28c79848-0cf6-4068-81c7-b79dddddf757

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2014 Araújo IJP.pdf
Size:
2.01 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito