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PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes

2014-11-05Journal article Restricted access
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dc.contributor.authorSilva, Stephane Edgar da
dc.contributor.authorSaraiva, Sofia M
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-20T15:07:51Z
dc.date.available2018-03-20T15:07:51Z
dc.date.issued2014-11-05
dc.description.abstractFungal infections affecting human beings have increased during the last years and the currently available treatments, when administered for long periods, trigger microbial resistance. Such demands the development of new viable therapeutic alternatives. Silver is known since the antiquity by its antimicrobial properties and, herein, it was used to produce two types of nanoparticles (NPs), uncoated and coated with polyvinylpyrrolidone (PVP), which were aimed to be used in fungal infection treatment. NPs properties were characterized by Transmission electron microscopy, X-ray diffraction, UV–Vis, Dynamic light scattering, Fourier transform infrared, and Energy-dispersive X-ray spectroscopy. Furthermore, in vitro studies were also performed to evaluate NPs cytotoxic profile and antifungal activity. The results obtained revealed that the produced nanoparticles are biocompatible and have a good potential for being used in the treatment of common skin infections caused by Trichophyton rubrum and Trichophyton mentagrophytes, being PVP-coated silver NPs the most suitable ones.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, E., Saraiva, S., Miguel, S.P. e Correia, I.J. (2014) “PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes”, Journal of Nanoparticle Research, Vol. 16:2726pt_PT
dc.identifier.doi10.1007/s11051-014-2726-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4664
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation2014 - Strategic Project
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11051-014-2726-2pt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectSilver nanoparticlespt_PT
dc.subjectFungal infectionspt_PT
dc.subjectPolyvinylpyrrolidonept_PT
dc.titlePVP-coated silver nanoparticles showing antifungal improved activity against dermatophytespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitle2014 - Strategic Project
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.citation.startPage2726pt_PT
oaire.citation.titleJournal of Nanoparticle Researchpt_PT
oaire.citation.volume16pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMENDES SARAIVA
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.givenNameSOFIA
person.givenNameSónia Alexandra
person.givenNameIlídio
person.identifierAAY-1488-2021
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id3511-F6AC-06F0
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-8849-804X
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57193545165
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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