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Preparation of Gel Forming Polymer-Based Sprays for First Aid Care of Skin Injuries

2024-04-25Journal article Open access
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dc.contributor.authorAlves, Patrícia
dc.contributor.authorLuzio, Diana
dc.contributor.authorSá, Kevin
dc.contributor.authorCorreia, I.J.
dc.contributor.authorFerreira, Paula
dc.date.accessioned2024-09-17T10:30:21Z
dc.date.available2024-09-17T10:30:21Z
dc.date.issued2024-04-25
dc.description.abstractCurrently, there are several types of materials for the treatment of wounds, burns, and other topical injuries available on the market. The most used are gauzes and compresses due to their fluid absorption capacity; however, these materials adhere to the surface of the lesions, which can lead to further bleeding and tissue damage upon removal. In the present study, the development of a polymer-based gel that can be applied as a spray provides a new vision in injury protection, respecting the requirements of safety, ease, and quickness of both applicability and removal. The following polymeric sprays were developed to further obtain gels based on different polymers: hydroxypropyl cellulose (HPC), polyvinyl pyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) using polyethylene glycol (PEG) as a plasticizer. The developed sprays revealed suitable properties for use in topical injuries. A protective film was obtained when sprayed on a surface through a casting mechanism. The obtained films adhered to the surface of biological tissue (pig muscle), turning into a gel when the exudate was absorbed, and proved to be washable with saline solution and contribute to the clotting process. Moreover, biocompatibility results showed that all materials were biocompatible, as cell viability was over 90% for all the materials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/gels10050297pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/14511
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.relationResearch Center in Natural Resources, Environment and Society
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2310-2861/10/5/297pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectWound carept_PT
dc.subjectPolymeric filmpt_PT
dc.subjectHemocompatibilitypt_PT
dc.subjectCytocompatibilitypt_PT
dc.titlePreparation of Gel Forming Polymer-Based Sprays for First Aid Care of Skin Injuriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemical Process Engineering and Forest Products Research Centre
oaire.awardTitleChemical Process Engineering and Forest Products Research Centre
oaire.awardTitleResearch Center in Natural Resources, Environment and Society
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00102%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00102%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00681%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00077%2F2021%2FCP2798%2FCT0001/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.titleGelspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2ed
person.familyNameAlves
person.familyNameSá
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNamePatrícia
person.givenNameKevin
person.givenNameIlídio
person.givenNamePaula
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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