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Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

2014-09Journal article Restricted access
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dc.contributor.authorFigueira, Marília I
dc.contributor.authorCardoso, HJ
dc.contributor.authorCorreia, Sara
dc.contributor.authorBaptista, Cláudio
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2019-12-02T17:16:45Z
dc.date.available2019-12-02T17:16:45Z
dc.date.issued2014-09
dc.description.abstractThe c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.proghi.2014.09.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAndrogenspt_PT
dc.subjectc-KITpt_PT
dc.subjectEstrogenspt_PT
dc.subjectGonadotropinspt_PT
dc.subjectInfertilitypt_PT
dc.titleHormonal regulation of c-KIT receptor and its ligand: implications for human infertility?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage19pt_PT
oaire.citation.issue1-3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleProgress in Histochemistry and Cytochemistrypt_PT
oaire.citation.volume49pt_PT
person.familyNameFigueira
person.familyNameCardoso
person.familyNameCorreia
person.familyNameMaia Baptista
person.familyNameSocorro
person.givenNameMarília
person.givenNameHenrique
person.givenNameSara
person.givenNameCláudio Jorge
person.givenNameSílvia Cristina da Cruz Marques
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id881D-B823-72F5
person.identifier.ciencia-id1B13-C5B8-72F8
person.identifier.ciencia-id7518-7FBC-A42F
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0003-0901-9931
person.identifier.orcid0000-0002-5750-2875
person.identifier.orcid0000-0001-9199-8360
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-8181-488X
person.identifier.scopus-author-id56421799300
person.identifier.scopus-author-id7004157751
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id23097994600
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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