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Novel synthetic opioids - toxicological aspects and analysis

2019Journal article Restricted access
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dc.contributor.authorTabarra, Inês Pires
dc.contributor.authorSoares, Sofia
dc.contributor.authorRosado, Tiago
dc.contributor.authorGonçalves, Joana
dc.contributor.authorLuís, Ângelo
dc.contributor.authorMalaca, Sara
dc.contributor.authorBarroso, Mário
dc.contributor.authorKeller, Thomas
dc.contributor.authorRestolho, José
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2020-01-28T16:30:19Z
dc.date.available2020-01-28T16:30:19Z
dc.date.issued2019
dc.description.abstractOver the past few years, there has been an emerging number of new psychoactive drugs. These drugs are frequently mentioned as "legal highs", "herbal highs", "bath salts" and "research chemicals". They are mostly sold and advertised on online forums and on the dark web. The emerging new psychoactive substances are designed to mimic the effects of psychoactive groups, which are often abused drugs. Novel synthetic opioids are a new trend in this context and represent an alarming threat to public health. Given the wide number of fatalities related to these compounds reported within the last few years, it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related substances. Clinicians dealing with fentanyl intoxication cases should consider that it could, in fact, be a fentanyl analogue. For this reason, it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures, including analysis in alternative matrices, if available, to investigate poly-drug use and possible tolerance to opioids. To address this public health problem, better international collaboration, effective legislation, effective investigation, control of suspicious "research chemicals" online forums and continuous community alertness are required. This article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology, metabolism, posology, available forms, as well as their toxic effects, highlighting the sample procedures and analytical techniques available for their detection and quantification in biological matrices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/20961790.2019.1588933pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8823
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectForensic sciencespt_PT
dc.subjectAnalysispt_PT
dc.subjectBiological specimenspt_PT
dc.subjectForensic toxicologypt_PT
dc.subjectNew synthetic opioidspt_PT
dc.subjectToxicitypt_PT
dc.titleNovel synthetic opioids - toxicological aspects and analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage140pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage111-140pt_PT
oaire.citation.titleForensic Sciences Researchpt_PT
oaire.citation.volume4pt_PT
oaire.fundingStream5876
person.familyNameSoares
person.familyNameRosado
person.familyNameGonçalves
person.familyNameSantos Luís
person.familyNameMalaca
person.familyNameBarroso
person.familyNameRestolho
person.familyNameGallardo
person.givenNameSofia
person.givenNameTiago
person.givenNameJoana
person.givenNameÂngelo Filipe
person.givenNameSara
person.givenNameMário
person.givenNameJosé
person.givenNameEugenia
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person.identifier.orcid0000-0002-2033-6746
person.identifier.orcid0000-0002-1802-8998
person.identifier.ridB-6330-2013
person.identifier.ridM-7410-2017
person.identifier.scopus-author-id57204097945
person.identifier.scopus-author-id57191891820
person.identifier.scopus-author-id35329243100
person.identifier.scopus-author-id24721485300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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