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Advisor(s)
Abstract(s)
A human respiratory syncytial virus surveillance system was implemented in
Florida in 1999, to support clinical decision-making for prophylaxis of
premature newborns. Recently, a local periodic SEIRS mathematical model was
proposed in [Stat. Optim. Inf. Comput. 6 (2018), no.1, 139--149] to describe
real data collected by Florida's system. In contrast, here we propose a
non-local fractional (non-integer) order model. A fractional optimal control
problem is then formulated and solved, having treatment as the control.
Finally, a cost-effectiveness analysis is carried out to evaluate the cost and
the effectiveness of proposed control measures during the intervention period,
showing the superiority of obtained results with respect to previous ones.
Description
Keywords
Human respiratory syncytial virus (HRSV) Compartmental mathematical models Fractional optimal control