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Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

2013-03-24Journal article Restricted access
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dc.contributor.authorRibeiro, MP.
dc.contributor.authorMorgado, Patrícia I.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCoutinho, Paula Isabel Teixeira Gonçalves
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-20T09:50:53Z
dc.date.available2018-03-20T09:50:53Z
dc.date.issued2013-03-24
dc.description.abstractSkin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and histological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, M.P., Morgado, P.I., Miguel, S.P., Coutinho, P. e Correia, I.J. (2013) "Dextran based-hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing", Materials Science & Engineering C - Materials for Biological Applications, Vol. 33(5), pp. 2958-66pt_PT
dc.identifier.doi10.1016/j.msec.2013.03.025pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4645
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationStrategic Project - UI 4056 - 2011-2012
dc.relationDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928493113001872pt_PT
dc.subjectWound healingpt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectGrowth factorspt_PT
dc.subjectIn vivo and in vitro studiespt_PT
dc.titleDextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleStrategic Project - UI 4056 - 2011-2012
oaire.awardTitleDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-TME%2F103375%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEGE%2FUI4056%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F80648%2F2011/PT
oaire.citation.endPage2966pt_PT
oaire.citation.startPage2958pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro
person.familyNameDa Cruz Morgado Ferreira
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.givenNameMaximiano
person.givenNamePatrícia Isabel
person.givenNameSónia Alexandra
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-idE71C-3D0E-821B
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0002-1005-9853
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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