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Hyaluronic acid and vitamin E polyethylene glycol succinate functionalized gold-core silica shell nanorods for cancer targeted photothermal therapy

2020-01-09Journal article Restricted access
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dc.contributor.authorJacinto, Telma A.
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorMoreira, André F.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCosta, Elisabete
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-01-15T11:18:25Z
dc.date.available2020-01-15T11:18:25Z
dc.date.issued2020-01-09
dc.description.abstractGold-core mesoporous silica shell (AuMSS) nanorods unique physicochemical properties makes them versatile and promising nanomedicines for cancer photothermal therapy. Nevertheless, these nanomaterials present a reduced half-life in the blood and poor specificity towards the tumor tissue. Herein, d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) and Hyaluronic Acid (HA) were combined for the first time to improve the AuMSS nanorods biological performance. The obtained results revealed that AuMSS surface functionalization induced the surface charge neutralization, from -28 ± 10 mV to −3 ± 5 mV and −10 ± 4 mV for AuMSS-TPGS-HA (1:1) and (4:1) formulations, without impacting on nanomaterials’ photothermal capacity. Moreover, the AuMSS functionalization improved the nanomaterials hemocompatibility and selectivity towards the cancer cells, particularly in the AuMSS-TPGS-HA (4:1) formulation. Furthermore, both formulations were able to mediate an on-demand photothermal effect, that induced the HeLa cancer cells death, confirming its potential for being applied as targeted multifunctional theragnostic nanomedicines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.colsurfb.2020.110778pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8302
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectGold core silica Shell nanoparticlespt_PT
dc.subjectHyaluronic acidpt_PT
dc.subjectCancerpt_PT
dc.subjectPhotothermal therapypt_PT
dc.titleHyaluronic acid and vitamin E polyethylene glycol succinate functionalized gold-core silica shell nanorods for cancer targeted photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage110778pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume188pt_PT
oaire.fundingStream5876
person.familyNameAndrade Jacinto
person.familyNameFélix Rodrigues
person.familyNameMoreira
person.familyNamePereira Miguel
person.familyNameda Rocha Costa
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameJoaquim Sobreira Correia
person.givenNameTelma Maria
person.givenNameAna Carolina
person.givenNameAndré Ferreira
person.givenNameSónia Alexandra
person.givenNameElisabete Cristina
person.givenNamePaula
person.givenNameIlídio
person.identifier1161643
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id2717-B57C-9AD7
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0135-2126
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57205459390
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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