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The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line

2024-07-04Artigo científico Acesso restrito
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dc.contributor.authorGonçalves, Joana
dc.contributor.authorCascalheira, José
dc.contributor.authorValentão, Patrícia
dc.contributor.authorLuís, Ângelo
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorDuarte, Ana Paula
dc.date.accessioned2024-07-04T11:26:30Z
dc.date.available2024-07-04T11:26:30Z
dc.date.issued2024-07-04
dc.description.abstractAyahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,Ndimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This study assessed the impact of extracts from three plant decoctions used in ayahuasca preparation on the gastric adenocarcinoma cell line (AGS). MTT reduction assays selected B. caapi, Mimosa hostilis, and Peganum harmala samples as most effective. Lactate dehydrogenase activity evaluated membrane integrity loss, while oxidative stress induction was measured using dihydroethidium and 2′,7′-dichlorodihydrofluorescein diacetate probes. Results revealed apoptosis induction in AGS Ucells, with all three samples significantly reducing oxidative stress.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/14786419.2024.2375315pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/14440
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre [UIDB/00709/2020]
dc.relationHealth Sciences Research Centre [UIDP/00709/2020]
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes [UIDP/50006/2020]
dc.relationBolsa de doutoramento FCT: Avaliação in vitro associados ao consumo de Ayahuasca [SFRH/BD/149360/2019]
dc.relationContrato de financiamento de emprego científico FCT [DL57/2016/CP1334/CP1644/CT0001]
dc.subjectAyahuascapt_PT
dc.subjectAGSpt_PT
dc.subjectApoptosispt_PT
dc.subjectOxidative stresspt_PT
dc.titleThe role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell linept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre [UIDB/00709/2020]
oaire.awardTitleHealth Sciences Research Centre [UIDP/00709/2020]
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes [UIDP/50006/2020]
oaire.awardTitleBolsa de doutoramento FCT: Avaliação in vitro associados ao consumo de Ayahuasca [SFRH/BD/149360/2019]
oaire.awardTitleContrato de financiamento de emprego científico FCT [DL57/2016/CP1334/CP1644/CT0001]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F149360%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL57%2F2016%2FCP1334%2FCP1644%2FCT0001/PT
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNatural Product Researchpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamDL 57/2016
person.familyNameGonçalves
person.familyNameCascalheira
person.familyNameRibeiro Valentão
person.familyNameLuís
person.familyNameGallardo
person.familyNameDuarte
person.givenNameJoana
person.givenNameJosé Francisco da Silva
person.givenNamePatrícia Carla
person.givenNameÂngelo Filipe Santos
person.givenNameEugenia
person.givenNameAna Paula
person.identifier908303
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person.identifier.orcid0000-0002-5315-3866
person.identifier.orcid0000-0002-0740-4396
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-1802-8998
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridM-7410-2017
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id24721485300
person.identifier.scopus-author-id7102602131
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofct© 2024 Informa UK Limited, trading as Taylor & Francis Grouppt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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