Repository logo
 
Publication

The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line

2024-07-04Journal article Restricted access
Simple item page
dc.contributor.authorGonçalves, Joana
dc.contributor.authorCascalheira, José
dc.contributor.authorValentão, Patrícia
dc.contributor.authorLuís, Ângelo
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorDuarte, Ana Paula
dc.date.accessioned2024-07-04T11:26:30Z
dc.date.available2024-07-04T11:26:30Z
dc.date.issued2024-07-04
dc.description.abstractAyahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,Ndimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This study assessed the impact of extracts from three plant decoctions used in ayahuasca preparation on the gastric adenocarcinoma cell line (AGS). MTT reduction assays selected B. caapi, Mimosa hostilis, and Peganum harmala samples as most effective. Lactate dehydrogenase activity evaluated membrane integrity loss, while oxidative stress induction was measured using dihydroethidium and 2′,7′-dichlorodihydrofluorescein diacetate probes. Results revealed apoptosis induction in AGS Ucells, with all three samples significantly reducing oxidative stress.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/14786419.2024.2375315pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/14440
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationalterado para: “Avaliação in vitro associados ao consumo de Ayahuasca” AVALIAÇÃO IN VITRO DOS EFEITOS TOXICOLÓGICOS ASSOCIADOS AO CONSUMO DE AYAHUASCA.
dc.relationNot Available
dc.subjectAyahuascapt_PT
dc.subjectAGSpt_PT
dc.subjectApoptosispt_PT
dc.subjectOxidative stresspt_PT
dc.titleThe role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell linept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitlealterado para: “Avaliação in vitro associados ao consumo de Ayahuasca” AVALIAÇÃO IN VITRO DOS EFEITOS TOXICOLÓGICOS ASSOCIADOS AO CONSUMO DE AYAHUASCA.
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F149360%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL57%2F2016%2FCP1334%2FCP1644%2FCT0001/PT
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNatural Product Researchpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamDL 57/2016
person.familyNameGonçalves
person.familyNameda Silva Cascalheira
person.familyNameRibeiro Valentão
person.familyNameSantos Luís
person.familyNameGallardo
person.familyNameDuarte
person.givenNameJoana
person.givenNameJosé Francisco
person.givenNamePatrícia Carla
person.givenNameÂngelo Filipe
person.givenNameEugenia
person.givenNameAna Paula
person.identifier908303
person.identifier1255684
person.identifier.ciencia-idB219-078D-FD06
person.identifier.ciencia-idCF15-A295-BC33
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-idF617-5CA5-EF61
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.orcid0000-0001-8702-415X
person.identifier.orcid0000-0002-5315-3866
person.identifier.orcid0000-0002-0740-4396
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-1802-8998
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridM-7410-2017
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id24721485300
person.identifier.scopus-author-id7102602131
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofct© 2024 Informa UK Limited, trading as Taylor & Francis Grouppt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdfccf1f9-70d0-435b-b121-0a55b1e35be3
relation.isAuthorOfPublicationc2e80b79-19f9-4175-94bf-5751fad1b460
relation.isAuthorOfPublication7b02d98a-edc9-4370-b2b1-37646060c5b3
relation.isAuthorOfPublicationa2d7c872-99db-41e1-9bc9-82c2d47b4661
relation.isAuthorOfPublication9763ebec-c3f5-4cc9-b5df-8d3c045ed4ec
relation.isAuthorOfPublication971779ac-7c22-4f69-8bdd-4e0ec442ef2d
relation.isAuthorOfPublication.latestForDiscoverya2d7c872-99db-41e1-9bc9-82c2d47b4661
relation.isProjectOfPublicationc7cee677-067c-47b2-ab19-b2dd5b0fda9d
relation.isProjectOfPublicationa4dfaeb8-2685-4a99-ba26-acc4e4a3d7c5
relation.isProjectOfPublicationbd704e80-5456-4a0e-b60b-553c7b84735e
relation.isProjectOfPublicationee79be19-94ff-4da5-86f6-1cfea260eb87
relation.isProjectOfPublication6fc718fa-0c18-497c-b609-c4b8c46e0cca
relation.isProjectOfPublication5262c171-0611-4fd3-929e-0afad6ffc7df
relation.isProjectOfPublication.latestForDiscoveryc7cee677-067c-47b2-ab19-b2dd5b0fda9d

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line.pdf
Size:
758.34 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
gnpl_a_2375315_sm3519.pdf
Size:
499.58 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ICI - CICS | Documentos por Auto-Depósito
Centros - UBIMEDICAL | Documentos por Auto-Depósito
FC - DQ | Documentos por Auto-Depósito