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Poly (vinyl alcohol)/chitosan layer-by-layer microneedles for cancer chemo-photothermal therapy

2020-02-25Journal article Restricted access
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dc.contributor.authorMoreira, André F.
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorJacinto, Telma A.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCosta, Elisabete
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-01-15T10:56:36Z
dc.date.available2020-01-15T10:56:36Z
dc.date.issued2020-02-25
dc.description.abstractThe combination of photothermal and chemo- therapies displays a high potential to increase the efficacy of the cancer treatments or even promote their eradication. In this study, the micromoulding and electrospraying techniques were combined to produce polyvinylpyrrolidone microneedles coated with chitosan and poly (vinyl alcohol) for mediating the delivery of doxorubicin and AuMSS nanorods (Dox@MicroN) to cancer cells. The microneedles' physicochemical characterization demonstrated that the electrospraying technique can be used to produce a layer-by-layer coating consisting of layers of doxorubicin-loaded chitosan and AuMSS enriched poly (vinyl alcohol). Further, the Dox@MicroN patches presented a good photothermal capacity leading to a temperature increase of 12 °C under near-infrared irradiation (808 nm, 1.7 W/cm-2 for 5 min), which in conjugation with the chitosan' pH sensitivity could be used to control the doxorubicin release. Moreover, the microneedles were able to penetrate the tumor-mimicking agarose gel and promote a layer dependent drug release. Additionally, the Dox@MicroN patches' capacity to simultaneously mediate the chemo- and photothermal-therapies rendered a superior cytotoxic effect against the cervical cancer cells. Overall, the Dox@MicroN patches demonstrated to be a simple macroscale delivery device that can be used to mediate the local administration of new drug-photothermal combinations, avoiding all the issues related to the systemic administration of anti-cancer therapeutics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2019.118907pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8299
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroneedlespt_PT
dc.subjectLayer-by-layerpt_PT
dc.subjectGold-core silica shell nanorodspt_PT
dc.subjectCombinatorial therapypt_PT
dc.subjectCancerpt_PT
dc.titlePoly (vinyl alcohol)/chitosan layer-by-layer microneedles for cancer chemo-photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage118907pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume576pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameFélix Rodrigues
person.familyNameAndrade Jacinto
person.familyNamePereira Miguel
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameAna Carolina
person.givenNameTelma Maria
person.givenNameSónia Alexandra
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifier1161643
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2717-B57C-9AD7
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0135-2126
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id57205459390
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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