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Sulfobetaine methacrylate-functionalized graphene oxide-IR780 nanohybrids aimed at improving breast cancer phototherapy

2020-10-14Journal article Open access
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dc.contributor.authorLeitão, Miguel
dc.contributor.authorAlves, Cátia
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-10-26T09:32:34Z
dc.date.available2020-10-26T09:32:34Z
dc.date.issued2020-10-14
dc.description.abstractThe application of Graphene Oxide (GO) in cancer photothermal therapy is hindered by its lack of colloidal stability in biologically relevant media and modest Near Infrared (NIR) absorption. In this regard, the colloidal stability of GO has been improved by functionalizing its surface with poly(ethylene glycol) (PEG), which may not be optimal due to the recent reports on PEG immunogenicity. On the other hand, the chemical reduction of GO using hydrazine hydrate has been applied to enhance its photothermal capacity, despite decreasing its cytocompatibility. In this work GO was functionalized with an amphiphilic polymer containing [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) brushes and was loaded with IR780, for the first time, aiming to improve its colloidal stability and phototherapeutic capacity. The attained results revealed that the SBMA-functionalized GO displays a suitable size distribution, neutral surface charge and adequate cytocompatibility. Furthermore, the SBMA-functionalized GO exhibited an improved colloidal stability in biologically relevant media, while its non-SBMA functionalized equivalent promptly precipitated under the same conditions. By loading IR780 into the SBMA-functionalized GO, its NIR absorption increased by 2.7-fold, leading to a 1.2 times higher photothermal heating. In in vitro cell studies, the combination of SBMA-functionalized GO with NIR light only reduced breast cancer cells' viability to 73%. In stark contrast, by combining IR780 loaded SBMA-functionalized GO and NIR radiation, the cancer cells' viability decreased to 20%, hence confirming the potential of this nanomaterial for cancer photothermal therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1039/D0RA07508Fpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10483
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Society of Chemistrypt_PT
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.subjectPhotothermal Therapy (PTT)pt_PT
dc.titleSulfobetaine methacrylate-functionalized graphene oxide-IR780 nanohybrids aimed at improving breast cancer phototherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.endPage38630pt_PT
oaire.citation.issue63pt_PT
oaire.citation.startPage38621pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameMarques Leitão
person.familyNameAlves
person.familyNameMiguel de Melo Diogo
person.familyNameSousa
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameMiguel
person.givenNameCátia Gomes
person.givenNameDuarte
person.givenNameAna Rita Lima
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A12-D674-B621
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-1029-4893
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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