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In vitro characterization of 3D printed scaffolds aimed at bone tissue regeneration

2018-02-21Journal article Restricted access
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dc.contributor.authorBoga, João Miguel Carvalho Freire
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorMendonça, António
dc.contributor.authorLouro, Ricardo
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-22T09:46:46Z
dc.date.available2018-03-22T09:46:46Z
dc.date.issued2018-02-21
dc.description.abstractThe incidence of fractures and bone-related diseases like osteoporosis has been increasing due to aging of the world’s population. Up to now, grafts and titanium implants have been the principal therapeutic approaches used for bone repair/regeneration. However, these types of treatment have several shortcomings, like limited availability, risk of donor-to-recipient infection and tissue morbidity. To overcome these handicaps, new 3D templates, capable of replicating the features of the native tissue, are currently being developed by researchers from the area of tissue engineering. These 3D constructs are able to provide a temporary matrix on which host cells can adhere, proliferate and differentiate. Herein, 3D cylindrical scaffolds were designed to mimic the natural architecture of hollow bones, and to allow nutrient exchange and bone neovascularization. 3D scaffolds were produced with tricalcium phosphate (TCP)/alginic acid (AA) using a Fab@home 3D printer. Furthermore, graphene oxide (GO) was incorporated into the structure of some scaffolds to further enhance their mechanical properties. The results revealed that the scaffolds incorporating GO displayed greater porosity, without impairing their mechanical properties. These scaffolds also presented a controlled swelling profile, enhanced biomineralization capacity and were able to increase the Alkaline Phosphatase (ALP) activity. Such characteristics make TCP/AA scaffolds functionalized with GO promising 3D constructs for bone tissue engineering applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBoga, J.C., Miguel, S.P., de Melo-Diogo, D., Mendonça, A.G., Louro, R.O., Correia, I.J. (2018) "In vitro characterization of 3D printed scaffolds aimed at bone tissue regeneration", Colloids and Surfaces B: Biointerfaces, Vol. 165, pp.207-218pt_PT
dc.identifier.doi10.1016/j.colsurfb.2018.02.038pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4705
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation2014 - Strategic Project
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0927776518301139pt_PT
dc.subjectBone tissue engineeringpt_PT
dc.subjectRapid prototypingpt_PT
dc.subject3D printingpt_PT
dc.subjectCylindrical hybrid scaffoldspt_PT
dc.subjectGraphene oxidept_PT
dc.titleIn vitro characterization of 3D printed scaffolds aimed at bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardTitle2014 - Strategic Project
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0709%2F2014/PT
oaire.citation.endPage218pt_PT
oaire.citation.startPage207pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume165pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePereira Miguel
person.familyNameMiguel de Melo Diogo
person.familyNameMendonça
person.familyNameLouro
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameDuarte
person.givenNameAntónio
person.givenNameRicardo
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
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person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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