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Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer phototherapy

dc.contributor.authorAlves, Cátia
dc.contributor.authorLima-Sousa, Rita
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorFerreira, Paula
dc.contributor.authorMoreira, André
dc.contributor.authorCorreia, I.J.
dc.contributor.authorde Melo-Diogo, Duarte
dc.date.accessioned2023-06-12T09:51:09Z
dc.date.embargo2025-06-09
dc.date.issued2023-02-21
dc.description.abstractConventional anticancer approaches are often associated with severe side effects. Herein, the authors assembled a novel nanoparticle whose therapeutic effect is triggered by laser light. In in vitro assays, the produced nanomaterial was able to, after interacting with laser light, reduce the viability of classic and advanced cancer models. In these conditions, but in the absence of laser light, no cytotoxicity was observed. In this way, the on-demand effect (triggered by laser light) may contribute to reduced side effects. Moreover, the produced nanoparticle revealed good stability, which is important for its future translation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2217/nnm-2022-0218pt_PT
dc.identifier.issn1743-5889
dc.identifier.urihttp://hdl.handle.net/10400.6/13354
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture medicinept_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectPoly(2-ethyl-2-oxazoline)pt_PT
dc.subjectPolymer–IR780 conjugatept_PT
dc.subjectSpheroidspt_PT
dc.titlePoly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer phototherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.06044.BD/PT
oaire.citation.conferencePlaceUKpt_PT
oaire.citation.endPage2072pt_PT
oaire.citation.issue27pt_PT
oaire.citation.startPage2057pt_PT
oaire.citation.titleNanomedicinept_PT
oaire.citation.volume17pt_PT
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameAlves
person.familyNameSousa
person.familyNameLopes Melo
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNameBruna Daniela
person.givenNamePaula
person.givenNameAndré Ferreira
person.givenNameIlídio
person.givenNameDuarte
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person.identifier.orcid0000-0003-4764-1967
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person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
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rcaap.embargofctOs direitos da publicação foram cedidos à editorapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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