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The sex bias of cancer

2020Journal article Open access
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dc.contributor.authorCosta, Ana Raquel
dc.contributor.authorCruz, Inês
dc.contributor.authorOliveira, Mariana Lança de
dc.contributor.authorGonçalves, Isabel
dc.contributor.authorCascalheira, José
dc.contributor.authorSantos, Cecilia
dc.date.accessioned2020-07-06T08:17:35Z
dc.date.available2021-07-01T00:30:13Z
dc.date.issued2020
dc.description.abstractIn cancers of hormone-dependent organs like women breast and reproductive organs, endometrium and ovaries, and men’s prostate and testicular cancer, the roles of sex hormones and deregulation of hormone axes are well-documented. More strikingly, epidemiological data highlights significant differences between sexes in the incidence of various cancers in non-reproductive organs, where the role of sex hormones has been less studied. In an era when personalised medicine is gaining recognition, understanding molecular, cellular and biological differences between men and women is timely for developing more appropriate therapeutic interventions according to gender. In this review we show that sex hormones also shape much of the deregulated cellular and molecular pathways leading to cell proliferation and cancer in nonreproductive organs.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10334
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.relationHealth Sciences Research Centre
dc.subjectGastrointestinal cancerspt_PT
dc.subjectGlioblastomapt_PT
dc.subjectBladder cancerpt_PT
dc.subjectThyroid cancerpt_PT
dc.subjectSex hormonespt_PT
dc.titleThe sex bias of cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIM-ONC%2F7121%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.titleTrends in Endocrinology and Metabolismpt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCosta
person.familyNameTheriaga Mendes Varanda Gonçalves
person.familyNameda Silva Cascalheira
person.familyNameSANTOS
person.givenNameAna Raquel
person.givenNameIsabel Maria
person.givenNameJosé Francisco
person.givenNameCecília Reis Alves
person.identifier.ciencia-id7D10-8378-9ABD
person.identifier.ciencia-idD916-0E13-ECB8
person.identifier.ciencia-idB219-078D-FD06
person.identifier.ciencia-id761A-7ED2-D68F
person.identifier.orcid0000-0002-9673-4337
person.identifier.orcid0000-0002-4384-8197
person.identifier.orcid0000-0002-5315-3866
person.identifier.orcid0000-0001-6074-7825
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctA Cell Press só permite partilha pública da versão aceite do artigo após um período de embargo de 12 meses.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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