Publication
The sex bias of cancer
| dc.contributor.author | Costa, Ana Raquel | |
| dc.contributor.author | Cruz, Inês | |
| dc.contributor.author | Oliveira, Mariana Lança de | |
| dc.contributor.author | Gonçalves, Isabel | |
| dc.contributor.author | Cascalheira, José | |
| dc.contributor.author | Santos, Cecilia | |
| dc.date.accessioned | 2020-07-06T08:17:35Z | |
| dc.date.available | 2021-07-01T00:30:13Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | In cancers of hormone-dependent organs like women breast and reproductive organs, endometrium and ovaries, and men’s prostate and testicular cancer, the roles of sex hormones and deregulation of hormone axes are well-documented. More strikingly, epidemiological data highlights significant differences between sexes in the incidence of various cancers in non-reproductive organs, where the role of sex hormones has been less studied. In an era when personalised medicine is gaining recognition, understanding molecular, cellular and biological differences between men and women is timely for developing more appropriate therapeutic interventions according to gender. In this review we show that sex hormones also shape much of the deregulated cellular and molecular pathways leading to cell proliferation and cancer in nonreproductive organs. | pt_PT |
| dc.description.version | info:eu-repo/semantics/acceptedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.6/10334 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | no | pt_PT |
| dc.relation | Health Sciences Research Centre | |
| dc.subject | Gastrointestinal cancers | pt_PT |
| dc.subject | Glioblastoma | pt_PT |
| dc.subject | Bladder cancer | pt_PT |
| dc.subject | Thyroid cancer | pt_PT |
| dc.subject | Sex hormones | pt_PT |
| dc.title | The sex bias of cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIM-ONC%2F7121%2F2014/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT | |
| oaire.citation.title | Trends in Endocrinology and Metabolism | pt_PT |
| oaire.fundingStream | 9471 - RIDTI | |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Costa | |
| person.familyName | Theriaga Mendes Varanda Gonçalves | |
| person.familyName | da Silva Cascalheira | |
| person.familyName | SANTOS | |
| person.givenName | Ana Raquel | |
| person.givenName | Isabel Maria | |
| person.givenName | José Francisco | |
| person.givenName | Cecília Reis Alves | |
| person.identifier.ciencia-id | 7D10-8378-9ABD | |
| person.identifier.ciencia-id | D916-0E13-ECB8 | |
| person.identifier.ciencia-id | B219-078D-FD06 | |
| person.identifier.ciencia-id | 761A-7ED2-D68F | |
| person.identifier.orcid | 0000-0002-9673-4337 | |
| person.identifier.orcid | 0000-0002-4384-8197 | |
| person.identifier.orcid | 0000-0002-5315-3866 | |
| person.identifier.orcid | 0000-0001-6074-7825 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | A Cell Press só permite partilha pública da versão aceite do artigo após um período de embargo de 12 meses. | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | f19b33f9-39fd-40cf-9d17-80129d6284da | |
| relation.isAuthorOfPublication | 763e9f1c-29f2-484c-9e9a-49f050dd18ff | |
| relation.isAuthorOfPublication | c2e80b79-19f9-4175-94bf-5751fad1b460 | |
| relation.isAuthorOfPublication | 21e86061-71ea-4cfa-bc85-0fcd6e847911 | |
| relation.isAuthorOfPublication.latestForDiscovery | c2e80b79-19f9-4175-94bf-5751fad1b460 | |
| relation.isProjectOfPublication | 5ff3f7a1-03d1-498a-83b1-65539d3c7487 | |
| relation.isProjectOfPublication | cb4688cf-40da-4197-9eb0-c55bad699ad3 | |
| relation.isProjectOfPublication | 5f81787a-0492-48ee-912a-13b4261dcee1 | |
| relation.isProjectOfPublication.latestForDiscovery | cb4688cf-40da-4197-9eb0-c55bad699ad3 |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- TEM combinepdf.pdf
- Size:
- 1.67 MB
- Format:
- Adobe Portable Document Format